Advanced Approaches to Post-Assembly Modification of Peptides by Transition-Metal-Catalyzed Reactions

Autor:	Nageswara Rao Panguluri, Sambasivarao Kotha, Milind Meshram
Rok vydání:	2019
Předmět:	Peptide modification 010405 organic chemistry Peptidomimetic Chemistry Negishi coupling Organic Chemistry Chemical modification 010402 general chemistry Metathesis 01 natural sciences Combinatorial chemistry Catalysis Cycloaddition 0104 chemical sciences Suzuki reaction Diels–Alder reaction
Zdroj:	Synthesis. 51:1913-1922
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0037-1612418
Popis:	We have summarized diverse synthetic approaches for the modification of peptides by employing transition-metal-catalyzed reactions. These methods can deliver unusual peptides suitable for peptidomimetics. To this end, several popular reactions such as Diels–Alder, 1,3-dipolar cycloaddition, [2+2+2] cyclotrimerization, metathesis, Suzuki­–Miyaura cross-coupling, and Negishi coupling have been used to assemble modified peptides by post-assembly chemical modification strategies.1 Introduction2 Synthesis of a Cyclic α-Amino Acid Derivative via a Ring-Closing Metathesis Protocol3 Peptide Modification Using a Ring-Closing Metathesis Strategy4 Peptide Modification via a [2+2+2] Cyclotrimerization Reaction5 Peptide Modification by Using [2+2+2] Cyclotrimerization and Suzuki Coupling6 Peptide Modification via a Suzuki–Miyaura Cross-Coupling7 Peptide Modification via Cross-Enyne Metathesis and a Diels–Alder­ Reaction as Key Steps8 Peptide Modification via 1,3-Dipolar Cycloaddition Reactions9 Modified Peptides via Negishi Coupling10 A Modified Dipeptide via Ethyl Isocyanoacetate11 Conclusions
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72167f9a70ba47f18d23cba07f4eb4ab https://doi.org/10.1055/s-0037-1612418 Zobrazit plný text záznamu