Lung cancer and the debrisoquine metabolic phenotype
| Autor: | Aimsley Weston, Gary M. Muschik, Linda W. Pickle, Neil E. Caporaso, Haleem J. Issaq, David J. Tollerud, Benjamin F. Trump, Seena C. Aisner, Margaret A. Tucker, Daina Buivys, Curtis C. Harris, James H. Resau, Robert N. Hoover, Richard B. Hayes, Laureen A. Green-Gallo |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Oncology
Male Risk Cancer Research medicine.medical_specialty Lung Neoplasms Debrisoquin Adenocarcinoma chemistry.chemical_compound Risk Factors Internal medicine medicine Humans Lung Diseases Obstructive Lung cancer Lung business.industry Smoking Case-control study Cancer Odds ratio Middle Aged medicine.disease Isoquinolines Confidence interval Endocrinology medicine.anatomical_structure Phenotype Debrisoquine chemistry Case-Control Studies Female business |
| Zdroj: | Journal of the National Cancer Institute. 82(15) |
| ISSN: | 0027-8874 |
| Popis: | In a case-control study, we tested the hypothesis that the genetically determined ability to metabolize debrisoquine is related to risk of lung cancer. Overall, individuals who were extensive metabolizers of debrisoquine were at significantly greater risk of lung cancer than those who were poor or intermediate metabolizers (odds ratio = 6.1; 95% confidence interval = 2.2-17.1). In this study, case patients had lung cancer, and control subjects had either chronic obstructive pulmonary disease or cancers other than lung cancer. Results were adjusted for age, race, asbestos exposure, and smoking. Both black and white individuals who were extensive metabolizers of debrisoquine were at significantly increased risk after similar adjustment (for blacks, odds ratio = 4.5, 95% confidence interval = 1.1-18.1; for whites, odds ratio = 10.2, 95% confidence interval = 2.0-51.4). Significantly increased risk of lung cancer was also present for individuals who were extensive metabolizers when subjects with chronic obstructive pulmonary disease or other cancers were considered separately. These data confirm that the ability to metabolize debrisoquine is a major determinant of susceptibility to lung cancer. Evaluation of the marker in other case-control settings, further exploration of racial differences, and the prospective evaluation of this marker in subgroups at high risk of lung cancer are areas worthy of further study. |
| Databáze: | OpenAIRE |
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