Influence of age and primary tumor size on the risk for residual/recurrent well-differentiated thyroid carcinoma
| Autor: | Jonathan Yip, Mark Dowar, Paul G. Walfish, Steven Orlov, Philip Dwek, Cindy Hu, Vafa Tabatabaie, Michael Shaytzag, David Orlov, Jeremy L. Freeman |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Neoplasm Residual medicine.medical_treatment Context (language use) Gastroenterology Risk Assessment Thyroglobulin Thyroid carcinoma Surgical pathology Cohort Studies Predictive Value of Tests Internal medicine Medicine Humans Thyroid Neoplasms Risk factor Survival analysis Aged Neoplasm Staging Probability Retrospective Studies Analysis of Variance business.industry Surrogate endpoint Age Factors Middle Aged Prognosis Survival Analysis Surgery Tumor Burden Logistic Models Treatment Outcome Otorhinolaryngology Predictive value of tests Female Neoplasm Recurrence Local business |
| Zdroj: | Headneck. 31(6) |
| ISSN: | 1097-0347 |
| Popis: | Background. Though age and primary tumor size predict cancer-specific survival in well-differentiated thyroid carcinoma (WDTC), their influence on residual/recurrent dis- ease has not been elucidated. Methods. In a retrospective study, residual/recurrent dis- ease was defined by the surrogate outcome of positive (� 2 lg/L) follow-up stimulated thyroglobulin after surgery and radi- oactive remnant ablation. Age, primary tumor size, and clinical staging systems were examined in the context of stimulated thyroglobulin outcome. Results. A total of 246 patients were followed up for a mean of 5.8 years. No significant difference in age (t(239) ¼ 0.61, p > .05) or tumor size (t(237) ¼ 0.16, p > .05) was found among patients with positive follow-up stimulated thyroglobulin compared with those with negative results. pTNM staging failed to demonstrate significant, stage-dependent increase in the percentage of patients with positive stimulated thyroglobu- lin, v 2 (2, N ¼ 229) ¼ 0.17, p > .05, unlike staging based solely on surgical pathology, v 2 (2, N ¼ 241) ¼ 34.97, p < .001. Conclusion. Age, primary tumor size, and pTNM staging do not predict risk for residual/recurrent WDTC, whereas extra- thyroidal extension at initial surgery is predictive. V |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text