Similar performance of liver stiffness measurement and liver surface nodularity for the detection of portal hypertension in patients with hepatocellular carcinoma
| Autor: | Riccardo Sartoris, O. Soubrane, Valérie Vilgrain, Maxime Ronot, François Cauchy, Dominique Valla, Elia Gigante, Laurent Castera, Alexandra Souhami, Valerio Giannelli, Mohamed Bouattour, François Durand, Pierre-Emmanuel Rautou |
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| Přispěvatelé: | Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Paris (UP), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
PHT
portal hypertension medicine.medical_specialty Cirrhosis Portal venous pressure [SDV]Life Sciences [q-bio] AUROC area under the receiver operating characteristic NRI Net Classification Index Improvement Gastroenterology 03 medical and health sciences 0302 clinical medicine CSPH clinically significant portal hypertension Liver stiffness Internal medicine Internal Medicine medicine Immunology and Allergy In patient lcsh:RC799-869 HVPG hepatic venous pressure gradient LSN liver surface nodularity Hepatology business.industry LSM liver stiffness measurements Mean age medicine.disease TE transient elastography 3. Good health LSPS LSM-spleen-size-to-platelet ratio score 030220 oncology & carcinogenesis Hepatocellular carcinoma Portal hypertension lcsh:Diseases of the digestive system. Gastroenterology 030211 gastroenterology & hepatology HCC hepatocellular carcinoma HPV hepatic venous pressure Transient elastography business Research Article |
| Zdroj: | JHEP Reports Innovation in Hepatology JHEP Reports Innovation in Hepatology, Elsevier, 2020, 2, pp.100147-. ⟨10.1016/j.jhepr.2020.100147⟩ JHEP Reports, Vol 2, Iss 5, Pp 100147-(2020) JHEP Reports |
| ISSN: | 2589-5559 |
| DOI: | 10.1016/j.jhepr.2020.100147⟩ |
| Popis: | Background & Aims We compare the performance of liver surface nodularity (LSN) and liver stiffness measurements (LSM) using transient elastography (TE) for the detection of clinically significant portal hypertension (CSPH) in patients with cirrhosis and hepatocellular carcinoma (HCC). Methods All patients with cirrhosis and HCC who underwent computed tomography, LSM and hepatic venous pressure gradient (HVPG) measurements within 30 days between 2015 and 2018 were included. The estimation of CSPH by LSN and LSM, and the LSM-spleen-size-to-platelet ratio score (LSPS) were evaluated and compared. Results In total, 140 patients were included (109 men [78%], mean age 63 ± 9 years old), including 39 (28%) with CSPH. LSN measurements were valid in 130 patients (93%) and significantly correlated with HVPG (r = 0.68; p 75% of patients. Such a combination could be useful in centres where the HVPG measurement is unavailable. Lay summary The diagnostic performance and feasibility of liver surface nodularity was similar to that of liver stiffness measurement (LSM) for the detection of clinically significant portal hypertension in patients with compensated cirrhosis. Thus, liver surface nodularity could be an option for the preoperative detection of clinically significant portal hypertension in patients with hepatocellular carcinoma. Combining liver surface nodularity with LSM-spleen-size-to-platelet ratio score resulted in the accurate detection of clinically significant portal hypertension in >75% of patients, thus limiting the need for HVPG measurements. Graphical abstract Highlights • Diagnostic performance of LSN is similar to that of LSM for the diagnosis of CSPH in patients with cirrhosis and HCC. • LSN could be useful for the preoperative detection of CSPH in patients with HCC and compensated cirrhosis. • Combination of LSN as a first-line non-invasive test and LSPS accurately detected CSPH in >75% of patients. |
| Databáze: | OpenAIRE |
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