Effects of Diuretic Agents on Serum and Tissue Electrolytes in Rats
| Autor: | Alexander P. Remenchik, Anthony F Cutilletta, Peter J. Talso |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
medicine.medical_specialty
Potassium medicine.medical_treatment Sodium chemistry.chemical_element Hypokalemia General Biochemistry Genetics and Molecular Biology Polythiazide Internal medicine medicine Animals Serum chloride Diuretics Thiazide Chlorthalidone Water-Electrolyte Balance Rats Blood Hydrochlorothiazide Endocrinology chemistry Diuretic medicine.symptom medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 122:78-81 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-122-31055 |
| Popis: | Summary and ConclusionsHydrochloro thiazide, polythiazide and chlorthalidone were added to the diets of 3 groups of Sprague-Dawley rats. After 4 weeks of subsistence on this diet, these animals together with matched controls were sacrificed and analyses of serum and tissue electrolytes were done. The serum chloride concentration was significantly lower in each experimental group. Serum potassium concentration was decreased in all 3 groups, and was significantly lowered in the groups receiving chlorthalidone and hydrochlorthiazide. Changes in serum sodium concentration were not statistically significant. Tissue analyses revealed no significant alterations in water or electrolyte content. These studies suggest that the hypokalemia associated with oral diuretic therapy results from a redistribution of potassium stores rather than a frank depletion of this ion in rats. |
| Databáze: | OpenAIRE |
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