The disruption of macaque CD4+ T-cell repertoires during the early simian immunodeficiency virus infection
| Autor: | Chris C. Ibegbu, Zheng W. Chen, Paul T. Morrison, Dejiang Zhou, Yun Shen, David Lee-Parritz, Prabhat K. Sehgal, Christine Bogle, Neetu Sehgal, Ling Shen, Harold M. McClure, Andre J. Nahmias, Zhongchen Kou |
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| Rok vydání: | 1999 |
| Předmět: |
Simian Acquired Immunodeficiency Syndrome
chemical and pharmacologic phenomena medicine.disease_cause Lymphocyte Activation Macaque Virus T-Lymphocyte Subsets biology.animal medicine Animals Receptor Dominance (genetics) General Veterinary Cd4 t cell biology T-cell receptor hemic and immune systems Simian immunodeficiency virus Virology Macaca mulatta CD4 Lymphocyte Count Clone Cells Peripheral blood lymphocyte Immunology CD4 Antigens Animal Science and Zoology Simian Immunodeficiency Virus Macaca nemestrina |
| Zdroj: | Journal of medical primatology. 28(4-5) |
| ISSN: | 0047-2565 |
| Popis: | T-cell receptor (TCR) complementarily determining region 3 (CDR3) spetratyping analysis was employed to assess the ability of an AIDS virus to disrupt CD4 + T-cell repertoires during the primary infection. Rhesus and pig-tailed macaques infected with simian immunodeficiency virus (SIV)mac 251 and SIVsmmFGb, respectively, were evaluated. Following SIV infection, the macaques exhibited an apparent decline of CD4 + peripheral blood lymphocyte (PBL) counts, which was associated with a change in CDR3 profiles from multiple-length distribution to one- or two-length dominance in the selected TCR Vbeta-expressing CD4 + PBL subpopulations. Molecular analysis of the perturbed cell subpopulations suggested that the CD4 + T cells bearing the dominant CDR3 length were clonally expanded. These results indicate that SIV infection can induce a disruption of macaque CD4 + T-cell repertoires during the primary infection. The finding in this study, therefore, suggests that the virus-induced clonal dominance can contribute to the disruption of CD4 + T-cell repertoires. |
| Databáze: | OpenAIRE |
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