Broad proteomic screen reveals shared serum proteomic signature in patients with psoriatic arthritis and psoriasis without arthritis
| Autor: | Weiyang Tao, Juliëtte N Pouw, Julia Drylewicz, Samuel E. DePrimo, Ernesto J. Muñoz-Elías, Marianne Boes, Tessa S. van Kempen, Deepak M.W. Balak, Timothy R D J Radstake, Aridaman Pandit, Emmerik F A Leijten, Janneke Tekstra, Michel Olde Nordkamp |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Adult Male Proteomics medicine.medical_specialty Arthritis Severity of Illness Index 03 medical and health sciences Psoriatic arthritis 0302 clinical medicine Rheumatology Psoriasis Area and Severity Index Internal medicine Psoriasis ankylosing spondylitis medicine Humans Pharmacology (medical) AcademicSubjects/MED00360 030203 arthritis & rheumatology psoriatic arthritis Ankylosing spondylitis business.industry Arthritis Psoriatic psoriasis Clinical Science spondyloarthritis medicine.disease Intercellular Adhesion Molecule-1 Blood proteins Prostate-specific antigen 030104 developmental biology Chemokines CC Biomarker (medicine) biomarker proximity extension assay Female business Biomarkers |
| Zdroj: | Rheumatology (Oxford, England) |
| ISSN: | 1462-0332 1462-0324 |
| Popis: | Objective To identify novel serum proteins involved in the pathogenesis of PsA as compared with healthy controls, psoriasis (Pso) and AS, and to explore which proteins best correlated to major clinical features of the disease. Methods A high-throughput serum biomarker platform (Olink) was used to assess the level of 951 unique proteins in serum of patients with PsA (n = 20), Pso (n = 18) and AS (n = 19), as well as healthy controls (HC, n = 20). Pso and PsA were matched for Psoriasis Area and Severity Index (PASI) and other clinical parameters. Results We found 68 differentially expressed proteins (DEPs) in PsA as compared with HC. Of those DEPs, 48 proteins (71%) were also dysregulated in Pso and/or AS. Strikingly, there were no DEPs when comparing PsA with Pso directly. On the contrary, hierarchical cluster analysis and multidimensional scaling revealed that HC clustered distinctly from all patients, and that PsA and Pso grouped together. The number of swollen joints had the strongest positive correlation to ICAM-1 (r = 0.81, P Conclusion PsA and Pso patients share a serum proteomic signature, which supports the concept of a single psoriatic spectrum of disease. Future studies should target skin and synovial tissues to uncover differences in local factors driving arthritis development in Pso. |
| Databáze: | OpenAIRE |
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