Characterisation of COPD heterogeneity in the ECLIPSE cohort

Autor: Alvar, Agusti, Peter M A, Calverley, Bartolome, Celli, Harvey O, Coxson, Lisa D, Edwards, David A, Lomas, William, MacNee, Bruce E, Miller, Steve, Rennard, Edwin K, Silverman, Ruth, Tal-Singer, Emiel, Wouters, Julie C, Yates, Jørgen, Vestbo, J, Yates
Přispěvatelé: Universitat de Barcelona, Pulmonologie, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Spirometry
Adult
Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Cross-sectional study
Population
NICE GUIDANCE
Disease
GUIDELINES
OBSTRUCTIVE PULMONARY-DISEASE
AIR-FLOW OBSTRUCTION
Cohort Studies
Pulmonary Disease
Chronic Obstructive
Clinical trials
Internal medicine
LUNG-FUNCTION DECLINE
MANAGEMENT
Medicine
Humans
Longitudinal Studies
Chronic obstructive pulmonary diseases
education
POPULATION
Malalties pulmonars obstructives cròniques
Aged
lcsh:RC705-779
COPD
education.field_of_study
Bronchiectasis
medicine.diagnostic_test
business.industry
Research
Smoking
NATURAL-HISTORY
lcsh:Diseases of the respiratory system
Middle Aged
respiratory system
medicine.disease
Respiratory Function Tests
respiratory tract diseases
Cross-Sectional Studies
Cohort
Physical therapy
Female
GENDER
business
Cohort study
Assaigs clínics
Zdroj: Respiratory Research, Vol 11, Iss 1, p 122 (2010)
Recercat. Dipósit de la Recerca de Catalunya
instname
Respiratory Research
Respiratory Research, 11. BioMed Central Ltd
Dipòsit Digital de la UB
Universidad de Barcelona
Agusti, A, Calverley, P M A, Celli, B, Coxson, H O, Edwards, L D, Lomas, D A, MacNee, W, Miller, B E, Rennard, S, Silverman, E K, Tal-Singer, R, Wouters, E & Yates, J C & Vestbo, J 2010, ' Characterisation of COPD heterogeneity in the ECLIPSE cohort ', Respiratory research, vol. 11, 122, pp.-. https://doi.org/10.1186/1465-9921-11-122
ISSN: 1465-9921
DOI: 10.1186/1465-9921-11-122
Popis: Background Chronic obstructive pulmonary disease (COPD) is a complex condition with pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in a large and well characterised and controlled COPD cohort (ECLIPSE). Methods We studied 2164 clinically stable COPD patients, 337 smokers with normal lung function and 245 never smokers. In these individuals, we measured clinical parameters, nutritional status, spirometry, exercise tolerance, and amount of emphysema by computed tomography. Results COPD patients were slightly older than controls and had more pack years of smoking than smokers with normal lung function. Co-morbidities were more prevalent in COPD patients than in controls, and occurred to the same extent irrespective of the GOLD stage. The severity of airflow limitation in COPD patients was poorly related to the degree of breathlessness, health status, presence of co-morbidity, exercise capacity and number of exacerbations reported in the year before the study. The distribution of these variables within each GOLD stage was wide. Even in subjects with severe airflow obstruction, a substantial proportion did not report symptoms, exacerbations or exercise limitation. The amount of emphysema increased with GOLD severity. The prevalence of bronchiectasis was low (4%) but also increased with GOLD stage. Some gender differences were also identified. Conclusions The clinical manifestations of COPD are highly variable and the degree of airflow limitation does not capture the heterogeneity of the disease.
Databáze: OpenAIRE
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