Three atypical serum creatine kinases in a patient with carcinoma of the colon
| Autor: | Mizushima Jun, Kawanishi Isami, Kanemitsu Fusae |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
Pathology medicine.medical_specialty Clinical Biochemistry Immunoglobulin light chain Biochemistry Isozyme Agar plate medicine Carcinoma Humans Urea Creatine Kinase Aged Electrophoresis Agar Gel biology Kinase business.industry Biochemistry (medical) General Medicine medicine.disease Molecular biology Immunoglobulin A Isoenzymes Immunoglobulin G Colonic Neoplasms Chromatography Gel biology.protein Serum creatine Creatine kinase business |
| Zdroj: | Clinica Chimica Acta. 112:275-283 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/0009-8981(81)90450-2 |
| Popis: | Three electrophoretically atypical creatine kinase (CK) bands were found simultaneously in the serum of a patient with terminal carcinoma of the colon. The atypical CKs were found at the cathodal side of CK-MB (CK-X1), at a sample application point (CK-X2), and at the anodal side of CK-MM (CK-X3) on agar plates. Our data seemed to suggest that CK-X1 was predominantly a CK-IgA/beta-lipoprotein complex, CK-X3 was a CK-IgG complex, and CK-X2 was macromolecular, different from both CK-X1 and CK-X3. The light chains of IgA and IgG were both of the lambda type. All native isoenzymes comprising these atypical CKs were identified as MM type. There was no change of the electrophoretic pattern of serum CK isoenzymes throughout the course of the study. |
| Databáze: | OpenAIRE |
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