Decreased density of benzodiazepine receptors in lymphocytes of anxious patients: reversal after chronic diazepam treatment
| Autor: | M. Perego, Ildebrando Appollonio, Maura Frigo, Lodovico Frattola, Carlo Ferrarese, R. Piolti, Marco Trabucchi |
|---|---|
| Přispěvatelé: | Ferrarese, C, Appollonio, I, Frigo, M, Perego, M, Piolti, R, Trabucchi, M, Frattola, L |
| Rok vydání: | 1990 |
| Předmět: |
Personality Tests
medicine.medical_specialty BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA Lymphocyte Down-Regulation Neuropsychological Tests Drug withdrawal Cell surface receptor Internal medicine medicine Humans Lymphocytes Receptor BIO/14 - FARMACOLOGIA Personality Test MED/26 - NEUROLOGIA Diazepam GABAA receptor business.industry Receptors GABA-A Ligand (biochemistry) medicine.disease Anxiety Disorders Long-Term Care Psychiatry and Mental health medicine.anatomical_structure Endocrinology MED/25 - PSICHIATRIA business Anxiety Disorder Anxiety disorder Human medicine.drug |
| Zdroj: | Acta Psychiatrica Scandinavica. 82:169-173 |
| ISSN: | 1600-0447 0001-690X |
| Popis: | Peripheral-type benzodiazepine receptors were measured in human circulating lymphocytes using 3H-PK 11195 as specific ligand. In a group of outpatients with anxiety disorders a significant decrease of receptor density (– 37%) was found compared with age-matched controls. In these patients long-term diazepam treatment restored binding density to normal levels: the effect persisted after drug withdrawal. Acute i.v. diazepam administration did not change receptor density. The observed receptor changes could reflect a down-regulation phenomenon and indicate that lymphocyte function reflect central nervous events. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text