Biomarkers of Exposure among Adult Smokeless Tobacco Users in the Population Assessment of Tobacco and Health Study (Wave 1, 2013-2014)
| Autor: | Brian L. Rostron, Jun Feng, Dorothy K. Hatsukami, Kevin P. Conway, Nicolette Borek, Andrew Hyland, Stephen S. Hecht, Kathryn C Edwards, Carmine Leggett, Lanqing Wang, Mark J. Travers, Heather L. Kimmel, Kristie Taylor, Carol H. Christensen, Baoyun Xia, Cynthia D. Ward, Charlie Lawrence, Benjamin C. Blount, Maciej L. Goniewicz, Jeffery M. Jarrett, Carolyn M. Reyes-Guzman, Yu Ching Cheng, Raymond Niaura, Dana M. van Bemmel |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male Nicotine Nitrosamines Tobacco Smokeless genetic structures Adolescent Epidemiology Population Article 03 medical and health sciences chemistry.chemical_compound Tobacco Use Young Adult 0302 clinical medicine Environmental health Prevalence Medicine Humans Longitudinal Studies Tobacco Use Epidemiology Young adult Polycyclic Aromatic Hydrocarbons education education.field_of_study Volatile Organic Compounds Smokers business.industry Middle Aged United States 030104 developmental biology Oncology chemistry Smokeless tobacco 030220 oncology & carcinogenesis Carcinogens Biomarker (medicine) Female business Risk assessment Biomarkers Toxicant medicine.drug |
| Zdroj: | Cancer Epidemiol Biomarkers Prev |
| ISSN: | 1538-7755 |
| Popis: | Background: Monitoring population-level toxicant exposures from smokeless tobacco (SLT) use is important for assessing population health risks due to product use. In this study, we assessed tobacco biomarkers of exposure (BOE) among SLT users from the Wave 1 (2013–2014) of the Population Assessment of Tobacco and Health (PATH) Study. Methods: Urinary biospecimens were collected from adults ages 18 and older. Biomarkers of nicotine, tobacco-specific nitrosamines (TSNA), polycyclic aromatic hydrocarbons (PAH), volatile organic compounds (VOC), metals, and inorganic arsenic were analyzed and reported among exclusive current established SLT users in comparison with exclusive current established cigarette smokers, dual SLT and cigarette users, and never tobacco users. Results: In general, SLT users (n = 448) have significantly higher concentrations of BOE to nicotine, TSNAs, and PAHs compared with never tobacco users; significant dose–response relationships between frequency of SLT use and biomarker concentrations were also reported among exclusive SLT daily users. Exclusive SLT daily users have higher geometric mean concentrations of total nicotine equivalent-2 (TNE2) and TSNAs than exclusive cigarette daily smokers. In contrast, geometric mean concentrations of PAHs and VOCs were substantially lower among exclusive SLT daily users than exclusive cigarette daily smokers. Conclusions: Our study produced a comprehensive assessment of SLT product use and 52 biomarkers of tobacco exposure. Compared with cigarette smokers, SLT users experience greater concentrations of some tobacco toxicants, including nicotine and TSNAs. Impact: Our data add information on the risk assessment of exposure to SLT-related toxicants. High levels of harmful constituents in SLT remain a health concern. |
| Databáze: | OpenAIRE |
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