Integrated analysis of the prognostic values ofRNA ‐binding proteins in head and neck squamous cell carcinoma
| Autor: | Jian-Xin Yue, Zeng-Hong Wu, Hongjun Xiao, Tao Zhou |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Spliceosome Clinical Biochemistry RNA transport RNA-binding protein Biology Biochemistry 03 medical and health sciences 0302 clinical medicine Biomarkers Tumor medicine Humans Gene Squamous Cell Carcinoma of Head and Neck Alternative splicing RNA-Binding Proteins RNA General Medicine Prognosis medicine.disease Head and neck squamous-cell carcinoma mRNA surveillance 030104 developmental biology Head and Neck Neoplasms 030220 oncology & carcinogenesis Cancer research Molecular Medicine |
| Zdroj: | BioFactors. 47:478-488 |
| ISSN: | 1872-8081 0951-6433 |
| DOI: | 10.1002/biof.1722 |
| Popis: | Head and neck squamous cell carcinoma is a malignant tumor of the upper aerodigestive tract. These RNA-binding proteins (RBPs) influence post-transcriptional in cells and regulate cell physiology, participate in regulating RNA stability, alternative splicing, translation, modification, localization, and apoptosis. We used RNA sequencing data from The Cancer Genome Atlas to display dysfunctional RBPs microenvironments and provide potential useful biomarkers for head and neck squamous cell carcinoma (HNSCC) diagnosis and prognosis. Six RBPs (DNMT1, PCF11, EIF5A2, RNASE10, PSMA6, and IGF2BP2) were selected as independent prognosis factors of HNSCC patients. The Kyoto Encyclopedia of Genes and Genomes were mainly enriched in RNA transport, Spliceosome, RNA degradation, mRNA surveillance pathway, and Epstein-Barr virus infection. cBioPortal results demonstrated that these six genes were altered in 150 samples out of 504 HNSCC patients (30%) and the amplification of IGF2BP2 was the largest frequent copy-number alteration. Based on the online database, we identified novel RBPs markers for the prognosis of HNSCC. |
| Databáze: | OpenAIRE |
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