Role of maternal glucocorticoid inducible kinase SGK1 in fetal programming of blood pressure in response to prenatal diet
| Autor: | Krishna M. Boini, Kan Wang, Ferruh Artunc, Dietmar Kuhl, Kerstin Amann, Jan J. Brosens, Rexhep Rexhepaj, Florian Lang, Dan Yang Huang |
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| Rok vydání: | 2008 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Physiology medicine.drug_class Hemodynamics Blood Pressure Protein Serine-Threonine Kinases Biology Immediate-Early Proteins Fetal Development Eating Mice Pregnancy Physiology (medical) Internal medicine medicine Animals Caloric Restriction Mice Knockout Sex Characteristics Fetus urogenital system Kinase Body Weight Sodium Maternal Nutritional Physiological Phenomena medicine.disease Malnutrition Endocrinology Blood pressure Mineralocorticoid Prenatal Exposure Delayed Effects Potassium SGK1 Female Dietary Proteins Corticosterone Glucocorticoid medicine.drug |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 294:R2008-R2013 |
| ISSN: | 1522-1490 0363-6119 |
| DOI: | 10.1152/ajpregu.00737.2007 |
| Popis: | Maternal stress and malnutrition modify intrauterine fetal development with impact on postnatal blood pressure, nutrient, water, and electrolyte metabolism. The present study explored the possible involvement of maternal serum- and glucocorticoid-inducible kinase (SGK)-1 in fetal programming of blood pressure. To this end, wild-type ( sgk1+/+) male mice were mated with SGK1 knockout ( sgk1−/−) female mice, and sgk1−/− males with sgk1+/+ females, resulting in both cases in heterozygotic ( sgk1−/+) offspring. Following prenatal protein restriction, the offspring of sgk1+/+ mothers gained weight significantly slower and had significantly higher blood pressure after birth. Moreover, a sexual dimorphism was apparent in fasting blood glucose and plasma corticosterone concentrations, with higher levels in female offspring. In contrast, prenatal protein restriction of sgk1−/− mothers had no significant effect on postnatal weight gain, blood pressure, plasma glucose concentration, or corticosterone levels, irrespective of offspring sex. Plasma aldosterone concentration, urinary flow rates, and urinary excretions of Na+ and K+ were not significantly modified by either maternal genotype or nutritional manipulation. In conclusion, maternal signals mediated by SGK1 may play a decisive role in fetal programming of hypertension induced by prenatal protein restriction. |
| Databáze: | OpenAIRE |
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