Free Versus Microencapsulated Pancreatic Islet Xenografts Producing Amelioration of Streptozotocin Toxicity
| Autor: | Tai It, Sun Am, Martin Krestow, Lum Zp |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte Blood Glucose Male endocrine system medicine.medical_specialty Pancreatic disease endocrine system diseases Drug Compounding Transplantation Heterologous Islets of Langerhans Transplantation Streptozocin Diabetes Mellitus Experimental Mice T-Lymphocyte Subsets Diabetes mellitus Internal medicine Animals Antigens Ly Medicine Cytotoxic T cell Blood glucose monitoring Mice Inbred BALB C geography geography.geographical_feature_category medicine.diagnostic_test business.industry Antibodies Monoclonal nutritional and metabolic diseases Rats Inbred Strains General Medicine medicine.disease Islet Streptozotocin Rats Endocrinology Toxicity business Normal blood glucose medicine.drug |
| Zdroj: | Biomaterials, Artificial Cells and Immobilization Biotechnology. 20:43-51 |
| ISSN: | 1055-7172 |
| DOI: | 10.3109/10731199209117857 |
| Popis: | This study examines the effect of pancreatic islet transplants on the streptozotocin(STZ)-associated toxicity in diabetic animals. Mice with STZ-induced diabetes were implanted with microencapsulated or free rat islets. The effectiveness of the transplant was evaluated in terms of: (A) blood glucose monitoring, (B) determination of subset levels of the helper and cytotoxic T-lymphocytes, and (C) STZ-associated mortality. The experimental results demonstrate that the transplanted islets can quickly restore normoglycemia. The restoration of normal blood glucose levels is accompanied by a significant increase in proportions of helper and cytotoxic T-cells. There was no mortality in the transplant recipients as a result of the STZ administrations, whereas a significant mortality was observed in the control group of mice. No significant differences between the encapsulated and free islet transplant recipients were observed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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