Molecular epidemiology, genetic variability and evolution of HTLV-1 with special emphasis on African genotypes
| Autor: | Philippe V. Afonso, Antoine Gessain, Olivier Cassar |
|---|---|
| Přispěvatelé: | Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology (EPVO (UMR_3569 / U-Pasteur_3)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), This work received the funding from the 'Investissement d’Avenir' as a part of the French Research Program 'Laboratoire d’Excellence' (LaBex): Integrative Biology of Emerging Infectious diseases (ANR10-LBX-62 IBEID)., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Mutation rate
[SDV]Life Sciences [q-bio] viruses Review Simian MESH: Africa MESH: Genotype 0302 clinical medicine Genotype MESH: Animals MESH: Genetic Variation MESH: Phylogeny Phylogeny MESH: Evolution Molecular Human T-lymphotropic virus 1 0303 health sciences Strain (biology) virus diseases 3. Good health MESH: Primates Infectious Diseases MESH: RNA Viral Molecular epidemiology RNA Viral Simian T-lymphotropic virus 1 Primates lcsh:Immunologic diseases. Allergy MESH: Mutation MESH: Simian T-lymphotropic virus 1 Evolution 030231 tropical medicine Genotypes Biology Virus Evolution Molecular 03 medical and health sciences Virology MESH: HTLV-I Infections Animals Humans MESH: Molecular Epidemiology Genetic variability 030304 developmental biology Genetic diversity MESH: Human T-lymphotropic virus 1 MESH: Humans Genetic Variation biology.organism_classification HTLV-I Infections Evolutionary biology HTLV-1 Mutation Africa lcsh:RC581-607 |
| Zdroj: | Retrovirology, Vol 16, Iss 1, Pp 1-15 (2019) Retrovirology Retrovirology, 2019, 16 (1), pp.39. ⟨10.1186/s12977-019-0504-z⟩ Retrovirology, BioMed Central, 2019, 16 (1), pp.39. ⟨10.1186/s12977-019-0504-z⟩ |
| ISSN: | 1742-4690 |
| DOI: | 10.1186/s12977-019-0504-z⟩ |
| Popis: | Human T cell leukemia virus (HTLV-1) is an oncoretrovirus that infects at least 10 million people worldwide. HTLV-1 exhibits a remarkable genetic stability, however, viral strains have been classified in several genotypes and subgroups, which often mirror the geographic origin of the viral strain. The Cosmopolitan genotype HTLV-1a, can be subdivided into geographically related subgroups, e.g. Transcontinental (a-TC), Japanese (a-Jpn), West-African (a-WA), North-African (a-NA), and Senegalese (a-Sen). Within each subgroup, the genetic diversity is low. Genotype HTLV-1b is found in Central Africa; it is the major genotype in Gabon, Cameroon and Democratic Republic of Congo. While strains from the HTLV-1d genotype represent only a few percent of the strains present in Central African countries, genotypes -e, -f, and -g have been only reported sporadically in particular in Cameroon Gabon, and Central African Republic. HTLV-1c genotype, which is found exclusively in Australo-Melanesia, is the most divergent genotype. This reflects an ancient speciation, with a long period of isolation of the infected populations in the different islands of this region (Australia, Papua New Guinea, Solomon Islands and Vanuatu archipelago). Until now, no viral genotype or subgroup is associated with a specific HTLV-1-associated disease. HTLV-1 originates from a simian reservoir (STLV-1); it derives from interspecies zoonotic transmission from non-human primates to humans (ancient or recent). In this review, we describe the genetic diversity of HTLV-1, and analyze the molecular mechanisms that are at play in HTLV-1 evolution. Similar to other retroviruses, HTLV-1 evolves either through accumulation of point mutations or recombination. Molecular studies point to a fairly low evolution rate of HTLV-1 (between 5.6E−7 and 1.5E−6 substitutions/site/year), supposedly because the virus persists within the host via clonal expansion (instead of new infectious cycles that use reverse transcriptase). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |