Interplay between exosomes, microRNAs and toll-like receptors in brain disorders
| Autor: | Silvia Honda Takada, Henning Ulrich, Juliane Midori Ikebara, Vera Paschon, Reza Raeisossadati, Alexandre Hiroaki Kihara, Erica de Sousa |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Nervous system Neuroscience (miscellaneous) Inflammation Biology APOPTOSE Exosomes RNA Transport Extracellular Vesicles 03 medical and health sciences Cellular and Molecular Neuroscience Paracrine signalling Immune system microRNA medicine Animals Humans Receptor Brain Diseases Toll-Like Receptors Neurodegeneration medicine.disease Microvesicles MicroRNAs 030104 developmental biology medicine.anatomical_structure Neurology medicine.symptom Neuroscience |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | Extracellular vesicles (EVs), including exosomes, microvesicles and apoptotic bodies, participate in intercellular communication, and particularly, in paracrine and endocrine signalling. The EVs and their specific contents have been considered hallmarks of different diseases. It has been recently discovered that EVs can co-transport nucleic acids such as DNAs, ribosomal RNAs, circular RNAs (circRNAs), long noncoding RNAs (lnRNAs) and microRNAs (miRNAs). miRNAs are important regulators of gene expression at the post-transcriptional level, although they may also play other roles. Recent evidence supports the hypothesis that miRNAs can activate Toll-like receptors (TLRs) under certain circumstances. TLRs belong to a multigene family of immune system receptors and have been recently described in the nervous system. In the immune system, TLRs are important for the recognition of the invading microorganisms, whereas in the nervous system, they recognise endogenous ligands released by undifferentiated or necrotic/injured cells. In the neuronal disease field, TLRs activity has been associated with amyotrophic lateral sclerosis (ALS), stroke, Alzheimer's and Parkinson's disease. Herein, we reviewed the current knowledge of the relationship between miRNA release by EVs and the inflammation signalling triggered by TLRs in neighbouring cells or during long-distance cell-to-cell communication. We highlight novel aspects of this communication mechanism, offering a valuable insight into such pathways in health and disease. |
| Databáze: | OpenAIRE |
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