Complementary Site‐Selective Halogenation of Nitrogen‐Containing (Hetero)Aromatics with Superacids

Autor:	Omar Karam, Fabien Zunino, Agnès Martin-Mingot, Sébastien Thibaudeau, Alexander Mamontov, Benoît Métayer, Fodil Bouazza
Rok vydání:	2020
Předmět:	Reaction mechanism 010405 organic chemistry Chemistry Organic Chemistry Halogenation chemistry.chemical_element Protonation General Chemistry Electrophilic aromatic substitution 010402 general chemistry 01 natural sciences Nitrogen Catalysis 0104 chemical sciences chemistry.chemical_compound Molecule Organic chemistry Surface modification Organic synthesis
Zdroj:	Chemistry – A European Journal. 26:10411-10416
ISSN:	1521-3765 0947-6539
DOI:	10.1002/chem.202000902
Popis:	Site-selective functionalization of arenes that is complementary to classical aromatic substitution reactions remains a long-standing quest in organic synthesis. Exploiting the generation of halenium ion through oxidative process and the protonation of the nitrogen containing function in HF/SbF5 , the chlorination and iodination of classically inert Csp2 -H bonds of aromatic amines occurs. Furthermore, the superacid-promoted (poly)protonation of the molecules acts as a protection, favoring the late-stage selective halogenation of natural alkaloids and active pharmaceutical ingredients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720171dd4ef57fac7c746ef21eb22f92 https://doi.org/10.1002/chem.202000902 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.