Potential Antiviral Xanthones from a Coastal Saline Soil Fungus Aspergillus iizukae
| Autor: | Mei-Jia Zhong, Hong Ren, Huai-Bin Zhang, Li-Ying Ma, De-Sheng Liu, Wei-Zhong Liu, Hui-Hui Kang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Stereochemistry
Electrospray ionization Pharmaceutical Science Mass spectrometry medicine.disease_cause 01 natural sciences chemistry.chemical_compound Drug Discovery Anthraquinones medicine Structure–activity relationship xanthones lcsh:QH301-705.5 Pharmacology Toxicology and Pharmaceutics (miscellaneous) Natural product Strain (chemistry) 010405 organic chemistry structure-activity relationship Aspergillus iizukae 0104 chemical sciences 010404 medicinal & biomolecular chemistry Herpes simplex virus lcsh:Biology (General) chemistry antiviral activity Lead compound |
| Zdroj: | Marine Drugs Volume 16 Issue 11 Marine Drugs, Vol 16, Iss 11, p 449 (2018) |
| ISSN: | 1660-3397 |
| DOI: | 10.3390/md16110449 |
| Popis: | Five new (1&ndash 5) and two known xanthones (6 and 7), one of the latter (6) obtained for the first time as a natural product, together with three known anthraquinones, questin, penipurdin A, and questinol, were isolated from the coastal saline soil-derived Aspergillus iizukae by application of an OSMAC (one strain many compounds) approach. Their structures were determined by interpretation of nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy (HRESIMS) data, as well as comparison of these data with those of related known compounds. Antiviral activity of xanthones 1&minus 7 was evaluated through the cytopathic effect (CPE) inhibition assay, and compound 2 exhibited distinctly strong activity towards influenza virus (H1N1), herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) with IC50 values of 44.6, 21.4, and 76.7 &mu M, respectively, which indicated that it was worth to further investigate it as a potential lead compound. The preliminary structure-activity relationship of the xanthones is discussed. |
| Databáze: | OpenAIRE |
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