The role of dopaminergic mechanisms of the brain in various models of anxious states
| Autor: | Yu. V. Stakhovskii, I. A. Abramets, Talalaenko An, Chernikov Av, Shevchenko Sl, Shekhovtsov Aa |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Microinjections medicine.drug_class Dopamine Anxiety Motor Activity Nucleus accumbens Anxiolytic GABA Antagonists chemistry.chemical_compound Tegmentum Animals Medicine Brain Chemistry Muscle Relaxants Central business.industry Receptors Dopamine D1 General Neuroscience Brain Rats Apomorphine chemistry Dopamine Agonists Dopamine Antagonists Midbrain tegmentum business Sulpiride Neuroscience Picrotoxin medicine.drug |
| Zdroj: | Neuroscience and Behavioral Physiology. 24:284-288 |
| ISSN: | 1573-899X 0097-0549 |
| DOI: | 10.1007/bf02362037 |
| Popis: | In tests of "illuminated area" and the "threatening situation" avoidance by rats, apomorphine and phenamine, administered intraperitoneally, attenuate the state of alarm. A similar effect is observed when sulpiride, a selective blocker of D2-receptors of dopamine, and of picrotoxin, a GABA antagonist, are administered. Sulpiride effectively counteracts the anxiolytic effects of all of the dopaminomimetics investigated and of picrotoxin. Haloperidol, a nonselective blocker of the D1- and D2-receptors of dopamine removes the anxiolytic effect of apomorphine, phenamine, and picrotoxin. The microinjection into the ventral region of the midbrain tegmentum of dopamine, or of sulpiride into the nucleus accumbens of the septum, attenuates the state of alarm formed by aversive influences of various biological modalities. By contrast, sulpiride, introduced locally into the tegmentum, or chemical stimulation of the nucleus accumbens of the septum by dopamine, intensifies the state of alarm in the "illuminated area" avoidance test. The participation of dopaminergic mechanisms of the mesolimbic system of the brain in anxiety of various aversive causations is discussed. |
| Databáze: | OpenAIRE |
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