Drug Exposure and Psoriasis Vulgaris: Case‐Control and Case‐Crossover Studies
| Autor: | Daniel A. Vardy, Dan Y. Bonneh, Haim Reuveni, Sima Halevy, Arnon D. Cohen, Lechaim Naggan |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Adrenergic beta-Antagonists Angiotensin-Converting Enzyme Inhibitors Dermatology Pharmacology Logistic regression Drug Prescriptions Severity of Illness Index Psoriasis Internal medicine Severity of illness medicine Humans Elective surgery Risk factor Cross-Over Studies business.industry Anti-Inflammatory Agents Non-Steroidal Case-control study General Medicine Middle Aged medicine.disease Crossover study Logistic Models Italy Case-Control Studies ACE inhibitor Female business medicine.drug |
| Zdroj: | Acta Dermato-Venereologica. 85:299-303 |
| ISSN: | 0001-5555 |
| Popis: | Intake of drugs is considered a risk factor for psoriasis. The aim of this study was to investigate the association between drugs and psoriasis. A case-control study including 110 patients who were hospitalized for extensive psoriasis was performed. A control group (n = 515) was defined as patients who had undergone elective surgery. A case-crossover study included 98 patients with psoriasis. Exposure to drugs was assessed during a hazard period (3 months before hospitalization) and compared to a control period in the patient's past. Data on drug sales were extracted by data mining techniques. Multivariate analyses were performed by logistic regression and conditional logistic regression. In the case-control study, psoriasis was associated with benzodiazepines (OR 6.9), organic nitrates (OR 5.0), angiotensin-converting enzyme (ACE) inhibitors (OR 4.0) and non-steroidal anti-inflammatory drugs (NSAIDs) (OR 3.7). In the case-crossover study, psoriasis was associated with ACE inhibitors (OR 9.9), beta-blockers (OR 9.9), dipyrone (OR 4.9) and NSAIDs (OR 2.1). Extensive psoriasis may be associated with intake of ACE inhibitors, NSAIDs or beta-blockers. |
| Databáze: | OpenAIRE |
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