Non-invasive early detection of cancer four years before conventional diagnosis using a blood test
| Autor: | Xiaorong Yang, Yajun Yang, Zhenhua Zhang, Rui Liu, Athurva Gore, Ziyu Yuan, Yuan Gao, Zhen Xie, Kun Zhang, Zhe Li, Chen Suo, Xiaojie Li, Min Fan, Yanfeng Jiang, He Qiye, Li Jin, Xiaofeng Wang, Xingdong Chen, Hongyu Niu, Juan Zhang, Tiejun Zhang, Weimin Ye, Catie McConnell, Ming Lu, Jun Min, Justin Dang, Shun-Zhang Yu, Jeffrey A. Gole, Jiucun Wang, Lei Cheng, Han Shi, Xiang Zhang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Epigenomics Longitudinal study General Physics and Astronomy Gastroenterology Circulating Tumor DNA Tumour biomarkers 0302 clinical medicine Neoplasms 80 and over Longitudinal Studies Young adult lcsh:Science Lung Early Detection of Cancer Cancer Aged 80 and over screening and diagnosis Multidisciplinary Tumor medicine.diagnostic_test Stomach High-Throughput Nucleotide Sequencing Middle Aged Primary tumor Healthy Volunteers Colo-Rectal Cancer Detection medicine.anatomical_structure 030220 oncology & carcinogenesis Female medicine.symptom Liver cancer 4.2 Evaluation of markers and technologies Genetic Markers Adult medicine.medical_specialty China Science Asymptomatic Sensitivity and Specificity Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Young Adult Rare Diseases Clinical Research Internal medicine Genetics Biomarkers Tumor medicine Blood test Humans Genetic Testing Aged business.industry Prevention Human Genome Reproducibility of Results General Chemistry DNA Methylation medicine.disease 4.1 Discovery and preclinical testing of markers and technologies 030104 developmental biology Next-generation sequencing lcsh:Q Digestive Diseases business Biomarkers |
| Zdroj: | Nature communications, vol 11, iss 1 Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020) Nature Communications |
| Popis: | Early detection has the potential to reduce cancer mortality, but an effective screening test must demonstrate asymptomatic cancer detection years before conventional diagnosis in a longitudinal study. In the Taizhou Longitudinal Study (TZL), 123,115 healthy subjects provided plasma samples for long-term storage and were then monitored for cancer occurrence. Here we report the preliminary results of PanSeer, a noninvasive blood test based on circulating tumor DNA methylation, on TZL plasma samples from 605 asymptomatic individuals, 191 of whom were later diagnosed with stomach, esophageal, colorectal, lung or liver cancer within four years of blood draw. We also assay plasma samples from an additional 223 cancer patients, plus 200 primary tumor and normal tissues. We show that PanSeer detects five common types of cancer in 88% (95% CI: 80–93%) of post-diagnosis patients with a specificity of 96% (95% CI: 93–98%), We also demonstrate that PanSeer detects cancer in 95% (95% CI: 89–98%) of asymptomatic individuals who were later diagnosed, though future longitudinal studies are required to confirm this result. These results demonstrate that cancer can be non-invasively detected up to four years before current standard of care. Patients whose disease is diagnosed in its early stages have better outcomes. In this study, the authors develop a non invasive blood test based on circulating tumor DNA methylation that can potentially detect cancer occurrence even in asymptomatic patients. |
| Databáze: | OpenAIRE |
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