Effect of obesity on molecular characteristics of invasive breast tumors: gene expression analysis in a large cohort of female patients
| Autor: | Allyson L. Toro, Darrell L. Ellsworth, Craig D. Shriver, Nicholas S. Costantino, Rachel E. Ellsworth |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Epidemiology Endocrinology Diabetes and Metabolism Physical Therapy Sports Therapy and Rehabilitation Overweight medicine.disease_cause Transcriptome 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine medicine Obesity Risk factor Lymph node business.industry Health Policy Public Health Environmental and Occupational Health Cancer medicine.disease 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Gene expression medicine.symptom business Carcinogenesis Research Article |
| Zdroj: | BMC obesity |
| ISSN: | 2052-9538 |
| Popis: | Background Obesity is a risk factor for breast cancer in postmenopausal women and is associated with decreased survival and less favorable clinical characteristics such as greater tumor burden, higher grade, and poor prognosis, regardless of menopausal status. Despite the negative impact of obesity on clinical outcome, molecular mechanisms through which excess adiposity influences breast cancer etiology are not well-defined. Methods Affymetrix U133 2.0 gene expression data were generated for 405 primary breast tumors using RNA isolated from laser microdissected tissues. Patients were classified as normal-weight (BMI |
| Databáze: | OpenAIRE |
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