Arylamine N-acetyltransferase 1 (NAT1) genotypes in a Lebanese population
| Autor: | Gerald N. Levy, Hassan R. Dhaini |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Linkage disequilibrium
Heterozygote Michigan Genotype Arylamine N-Acetyltransferase Population Population genetics Biology Polymerase Chain Reaction Gene Frequency Acetyltransferases Genetics Humans Genetic Testing General Pharmacology Toxicology and Pharmaceutics Allele Lebanon education Genotyping Alleles education.field_of_study Genetic Carrier Screening Acetylation Zygosity Genotype frequency Isoenzymes Mutation Polymorphism Restriction Fragment Length |
| Zdroj: | Pharmacogenetics. 10(1) |
| ISSN: | 0960-314X |
| Popis: | The frequency distributions of human N-acetyltransferase 1 (NAT1 * ) alleles in various ethnic groups are largely unknown. This lack of information is in contrast to the many studies of ethnic differences in NAT2 * alleles and phenotypes. Increasing interest in NAT1 due to its potential roles in carcinogen metabolism and cancer risk makes it desirable to know the distribution of NAT1 * alleles in various populations. Using a polymerase chain reaction-restriction fragment length polymorphism genotyping assay, the frequency of NAT1 * alleles in a Lebanese population was determined. Of 84 NAT1 * alleles assayed, 56% were NAT1 * 4. Alleles NAT1 * 3, * 10, and * 14 were found at frequencies of 0.036, 0.107, and 0.238, respectively. Five additional alleles (6%) differed from previously reported alleles. Nearly 50% of the population were heterozygous for a NAT1 * 14 allele. The unusually high frequency of NAT1 * 14 alleles in Lebanese may be useful for epidemiological studies of the effects of the NAT1 polymorphism in this population. |
| Databáze: | OpenAIRE |
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