Clade 2.3.4.4 avian influenza A (H5N8) outbreak in commercial poultry, Iran, 2016: the first report and update data
| Autor: | Hossein Maghsoudloo, Hamed Abdollahi, F Tehrani, Arash Ghalyanchilangeroudi, Mohammad Hossein Fallah, Reza Kh Farahani, Seyed Ali Ghafouri |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Lineage (genetic) animal diseases viruses 030106 microbiology Hemagglutinins Viral Neuraminidase Iran medicine.disease_cause Polymerase Chain Reaction Virus Poultry Disease Outbreaks 03 medical and health sciences Goose Food Animals biology.animal medicine Animals Clade Phylogeny Poultry Diseases Phylogenetic tree biology Sequence Analysis RNA food and beverages virus diseases Outbreak Virology Influenza A virus subtype H5N1 030104 developmental biology Influenza A virus Influenza in Birds biology.protein Animal Science and Zoology |
| Zdroj: | Tropical animal health and production. 49(5) |
| ISSN: | 1573-7438 |
| Popis: | In 2010, H5N8 highly pathogenic avian influenza (HPAI) viruses of the A/Goose/Guangdong/1/1996 lineage dramatically affected poultry and wild birds in Asia, Europe, and North America. In November 2016, HPAI H5N8 was detected in a commercial layer farm in Tehran province. The diagnosis was based on real-time reverse transcriptase PCR (RRT-PCR) and sequencing of haemaglutinin (HA) and neuraminidase (NA) genes from suspected samples. Genetic and phylogenetic analysis of the HA gene demonstrated that the Iranian HPAI H5N8 viruses belong to the HPAI H5 virus clade 2.3.4.4 and cluster within group B (Gochang-like). In particular, the highest similarity was found with the sequences of the HPAI H5N8 identified in Russia in 2016. To our knowledge, this clade has not been previously detected in Iran. Previous HPAI A (H5) epidemic in Iran occurred in 2015 and involved exclusively viruses of clade 2.3.2.1c. These findings indicate that Iran is at high risk of introduction of HPAI H5 of the A/Goose/Guangdong/1/1996 lineage from East Asia and highlight the need to maintain adequate monitoring activities in target wild and domestic bird species for HPAI early detection. This study is useful for better understanding the genetic and antigenic evolution of H5 HPAI viruses in the region and the world. |
| Databáze: | OpenAIRE |
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