Enhancement of Primary Antigen-Specific Resistance in Infant Mice with Divinyl Ether-Maleic Anhydride

Autor:	J. Y. Richmond, C. H. Campbell
Rok vydání:	1974
Předmět:	Immunology Maleic anhydride Antibody level Ether Biology Microbiology Molecular biology Viral Infections chemistry.chemical_compound Infectious Diseases chemistry Antigen Antigen specific biology.protein Parasitology Antibody Neutralizing antibody Viral antigens
Zdroj:	Infection and Immunity. 10:1029-1033
ISSN:	1098-5522 0019-9567
DOI:	10.1128/iai.10.5.1029-1033.1974
Popis:	The early response of infant mice to foot-and-mouth disease viral antigens, measured by greater resistance and increased serum-neutralizing antibody, was enhanced by divinyl ether-maleic anhydride (DVE/MA). Preparations of known antigen concentration were used to study various parameters influencing this enhancement. Resistance and antibody levels were increased when DVE/MA was administered with aqueous or oil-emulsified antigens, whether given separately or mixed with the antigens, but was dependent on the dose and route of the DVE/MA and antigen. Enhanced resistance developed rapidly, was antigen-specific, and may have been related to the level of neutralizing antibody.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f49ec9f07adeadde9aeee69f449093 https://doi.org/10.1128/iai.10.5.1029-1033.1974 Zobrazit plný text záznamu