Annexin II incorporated into influenza virus particles supports virus replication by converting plasminogen into plasmin
| Autor: | Fanny LeBouder, Bernard Delmas, Eric Morello, Françoise Bosse, Guus F. Rimmelzwaan, Béatrice Riteau, Christine Péchoux |
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| Přispěvatelé: | Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Institut National de la Recherche Agronomique (INRA), Erasmus University Rotterdam, Unité de recherche génomique et physiologie de la lactation (GPL), Virology |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Proteases
VIRUS DE LA GRIPPE Plasmin viruses Immunology Orthomyxoviridae PATHOGENICITE Biology medicine.disease_cause Virus Replication Microbiology Virus Cell Line REPLICATION DU VIRUS 03 medical and health sciences Dogs Influenza A Virus H1N1 Subtype Annexin Virology medicine Influenza A virus Animals Fibrinolysin Annexin A2 030304 developmental biology 0303 health sciences 030306 microbiology Influenza A Virus H3N2 Subtype Plasminogen biology.organism_classification 3. Good health VIROLOGIE Viral replication Insect Science [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Pathogenesis and Immunity medicine.drug Protein Binding |
| Zdroj: | Journal of Virology Journal of Virology, American Society for Microbiology, 2008, 82 (14), pp.6820-6828. ⟨10.1128/JVI.00246-08⟩ Journal of Virology, 82(14), 6820-6828. American Society for Microbiology |
| ISSN: | 0022-538X 1098-5514 |
| DOI: | 10.1128/JVI.00246-08⟩ |
| Popis: | For influenza viruses to become infectious, the proteolytic cleavage of hemagglutinin (HA) is essential. This usually is mediated by trypsin-like proteases in the respiratory tract. The binding of plasminogen to influenza virus A/WSN/33 leads to the cleavage of HA, a feature determining its pathogenicity and neurotropism in mice. Here, we demonstrate that plasminogen also promotes the replication of other influenza virus strains. The inhibition of the conversion of plasminogen into plasmin blocked influenza virus replication. Evidence is provided that the activation of plasminogen is mediated by the host cellular protein annexin II, which is incorporated into the virus particles. Indeed, the inhibition of plasminogen binding to annexin II by using a competitive inhibitor inhibits plasminogen activation into plasmin. Collectively, these results indicate that the annexin II-mediated activation of plasminogen supports the replication of influenza viruses, which may contribute to their pathogenicity. |
| Databáze: | OpenAIRE |
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