Drinking green tea alleviates alveolar bone resorption in ligature-induced periodontitis in mice
Autor: | Boosana Kaboosaya, Shohei Kasugai, V.N. Trang Nguyen, Lia Kartika Wulansari |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Male medicine.medical_specialty Antioxidant medicine.medical_treatment Alveolar Bone Loss Medicine (miscellaneous) Osteoclasts General Biochemistry Genetics and Molecular Biology Bone resorption 03 medical and health sciences Mice 0302 clinical medicine Internal medicine medicine Animals Ligature Periodontitis General Dentistry Dental alveolus Tea business.industry 030206 dentistry Buccal administration medicine.disease Resorption Mice Inbred C57BL 030104 developmental biology Endocrinology Maxilla business |
Zdroj: | Journal of oral biosciences. 62(2) |
ISSN: | 1880-3865 |
Popis: | Objectives It has been reported that green tea exerts antibacterial, anti-inflammatory, and antioxidant effects. The purpose of the present study was to evaluate the effects of drinking green tea on bone resorption in ligature-induced periodontitis in mice. Methods Sixty C57BL/6 eight-week-old male mice were used. To induce periodontitis, a ligature was placed for 7 days around the upper left second maxillary molar. After ligature removal, the animals were administered different concentrations of green tea (1.5 g/60 mL, 3 g/60 mL, or 6 g/60 mL) or distilled water. At 1 and 2 weeks of administration, the animals were sacrificed and micro-CT images of the maxillae were taken. Next, the depth and area of alveolar bone loss in the buccal and palatal sides were measured. The number of inflammatory cells and osteoclasts in histological sections were counted. Results The result showed ligature-induced alveolar bone loss. Green tea inhibited ligature-induced bone loss in the buccal side in a dose-dependent manner. Histologically, ligature increased the number of inflammatory cells and osteoclasts, but this effect was alleviated by green tea. Conclusions Evidence from this animal experiment suggested that drinking green tea would be potentially beneficial to reduce alveolar bone loss in ligature-induced periodontitis. |
Databáze: | OpenAIRE |
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