Role of MicroRNA Profile Modifications in Hepatitis C Virus-Related Mixed Cryoglobulinemia

Autor: Elisa Fognani, Giacomo Laffi, T. Urraro, J. Ranieri, Monica Monti, E. Triboli, P. Caini, Carlo Giannini, Laura Gragnani, Alessia Piluso, Anna Linda Zignego
Rok vydání: 2013
Předmět:
Male
Epidemiology
Gastroenterology and hepatology
Hepacivirus
lcsh:Medicine
medicine.disease_cause
Pathogenesis
RNA interference
Molecular cell biology
Mixed Cryoglobulinemia
hemic and lymphatic diseases
Pathology
Medicine
lcsh:Science
Multidisciplinary
biology
virus diseases
MicroRNA
Middle Aged
Hepatitis C
Cryoglobulinemia
HCV infection
non-Hodgkin’s Lymphoma
Infectious hepatitis
Hepatocellular carcinoma
Biomarker (medicine)
Female
Research Article
Vasculitis
Hepatitis C virus
Lymphoproliferative disorders
Microbiology
Viral Evolution
Autoimmune Diseases
Rheumatology
Diagnostic Medicine
Virology
Genetics
Humans
Biology
Liver diseases
Aged
business.industry
lcsh:R
Hepatitis C
Chronic
medicine.disease
biology.organism_classification
Lymphoproliferative Disorders
digestive system diseases
Lymphoma
MicroRNAs
Biomarker Epidemiology
Case-Control Studies
Immunology
Clinical Immunology
lcsh:Q
Gene expression
Transcriptome
business
Biomarkers
General Pathology
Zdroj: PLoS ONE, Vol 8, Iss 5, p e62965 (2013)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0062965
Popis: Hepatitis C virus infection is closely related to lymphoproliferative disorders (LPDs), including mixed cryoglobulinemia (MC) and some lymphomas. Modification of the expression of specific microRNAs (miRNAs) has been associated with different autoimmune diseases and/or LPDs. No data exist about the modifications in miRNA expression in HCV-associated LPDs. The aim of this study was to analyze the expression levels of a panel of miRNAs previously associated with autoimmune/LPDs in a large population of HCV patients with and without MC or non-Hodgkin’s lymphoma (NHL), to identify potential markers of evolution of HCV infection. PBMC expression of miR-Let-7d, miR-16, miR-21, miR-26b, miR-146a and miR-155 was evaluated by real-time PCR in 167 HCV patients (75 with MC [MC-HCV], 11 with HCV-associated NHL [NHL-HCV], 81 without LPD [HCV]) and in 35 healthy subjects (HS). A significant increase in miR-21 (p
Databáze: OpenAIRE
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