Liraglutide effects on glycemic control and weight in patients with Type 2 Diabetes mellitus: a real-world, observational study and brief narrative review
| Autor: | Raneem Mohammad Aljohani, Consuela Cheriece Yousef, Alya Najeeb Balubaid, Ibrahim Aldossary, Lama Ghandoura, Sarah Musa Almuhanna, Fatmh Bisher Al Bisher, Reem Alamoudi, Mahmoud Ismail Nouh, Abdulhalim Almurashi, Fatimah Alhussain, Manar Al Matar, Abin Thomas |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes Glycemic Control 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Diabetes mellitus Internal Medicine medicine Humans Hypoglycemic Agents 030212 general & internal medicine Glucagon-like peptide 1 receptor Glycemic Glycated Hemoglobin Liraglutide business.industry Type 2 Diabetes Mellitus General Medicine medicine.disease Observational Studies as Topic Diabetes Mellitus Type 2 Observational study medicine.symptom business Weight gain medicine.drug |
| ISSN: | 0168-8227 |
| Popis: | Background\udGlycemic control and weight gain are two essential considerations in the pharmacological management of type 2 diabetes mellitus. Pharmacological agents are effective in lowering blood glucose levels but may result in significant weight gain. Liraglutide effectively maintains glycemic control while reducing weight.\udMethods\udThis is a real-world study and brief narrative review of the effects of liraglutide on glycemic control and weight in adult patients with type 2 diabetes mellitus. The study uses data extracted from the electronic health record of the Ministry of National Guard-Health Affairs.\udResults\udIn this study of 348 subjects, there was a statistically significant reduction in hemoglobin A1c of 0.9% (P < .0001) and weight of 2.3 kg (P < .0001). The majority (77.3%) were on concomitant insulin. Subjects with a baseline hemoglobin A1c greater than 9% had a significantly greater reduction than those below 9% (−0.7%; P < .0001). Those with a weight more than 100 kg had a significantly greater reduction than those below 100 kg (-0.9 kg; P = .0096).\udConclusion\udIn this real-world, observational study, liraglutide was shown to be effective in improving glycemic control and reducing weight in adult patients with type 2 diabetes mellitus. |
| Databáze: | OpenAIRE |
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