Breast cancer subtypes identified by the ER, PR and HER-2 status in Thai women
| Autor: | Malee Warnnissorn, Poramaporn Prasarttong Osoth, C. Akewanlop, Watthanasak Permsapaya, Vorapan Sirivatanauksorn, Suebwong Chuthapisith |
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| Rok vydání: | 2012 |
| Předmět: |
Oncology
Adult Cancer Research medicine.medical_specialty Pathology Epidemiology Receptor ErbB-2 Breast Neoplasms Immunoenzyme Techniques Tumor grade Breast cancer Nodal status Internal medicine Carcinoma medicine Humans Neoplasm Invasiveness Nodal involvement Aged Aged 80 and over Tumor size business.industry Carcinoma Ductal Breast Public Health Environmental and Occupational Health Gene Microarray Middle Aged medicine.disease Prognosis Thailand Receptors Estrogen Carcinoma Basal Cell Thai women Female Neoplasm Grading business Receptors Progesterone |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 13(2) |
| ISSN: | 2476-762X |
| Popis: | Expression of estrogen-receptor (ER), progesterone-receptor (PR) and HER-2 has recently been linked with various breast cancer subtypes identified by gene microarray. This study aimed to document breast cancer subtypes based on ER, PR and HER-2 status in Thai women, where expression of these subtypes may not be similar to those evident in Western women. During 2009 to 2010, histological findings from 324 invasive ductal carcinomas (IDC) at Siriraj Hospital were studied. Various subtypes of IDC were identified according to expression of ER, PR and HER-2: luminal-A (ER+;PR+/-;HER-2–), luminal-B (ER+;PR+/-;HER-2 +), HER-2 (ER-;PR;HER-2+) and basal-like (ER-;PR-;HER-2–). As well, associations of tumor size, tumor grade, nodal status, angiolymphatic invasion (ALI), multicentricity and multifocality with different breast cancer subtypes were studied. Of 324 IDCs, 143 (44.1%), 147 (45.4%), 15 (4.6%) and 12 (3.7%) were T1, T2, T3 and T4, respectively. Most tumors were grade 2 (54.9%) and had no nodal involvement (53.4%). According to ER, PR and HER-2 status, 192 (59.3%), 40 (12.3%), 43 (13.3%) and 49 (15.1%) tumors were luminal-A, luminal-B, HER-2 and basal-like subtypes. HER-2 subtype presented with large tumor (p=0.04, ANOVA). Luminal-A IDC was associated with single foci (p |
| Databáze: | OpenAIRE |
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