Metabolic parameters and cognitive function in a cohort of older diabetic patients
| Autor: | Anna Marie Herghelegiu, Raluca Mihaela Nacu, Gabriel Ioan Prada |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Gerontology
Male Aging medicine.medical_specialty Statistics as Topic 030209 endocrinology & metabolism Comorbidity Body Mass Index 03 medical and health sciences 0302 clinical medicine Cognition Bayesian multivariate linear regression Internal medicine Diabetes mellitus medicine Diabetes Mellitus Prevalence Dementia Humans Pathological Geriatric Assessment Aged Aged 80 and over Glycated Hemoglobin Intelligence Tests business.industry Romania Cholesterol LDL medicine.disease Metabolic control analysis Cohort Life expectancy Female Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | Aging clinical and experimental research. 28(6) |
| ISSN: | 1720-8319 |
| Popis: | Dementia is one of the most disabling conditions associated with old age. With increasing life expectancy, prevalence of both dementia and diabetes is rising. The complex pathological relationship between diabetes mellitus (DM) and dementia has been studied, but is not yet fully understood. The main objective of this study was to investigate the relationship between metabolic parameters and the cognitive function in older diabetics. A total number of 360 diabetic subjects, age 65 years and over, and 300 older people controls were included. Clinical and biological parameters, together with the cognitive function, were assessed every 6 months over a 18-month period, for each study participant. By employing a multivariate linear regression analysis, several significant relationships have been identified: between Clock Drawing Test (CDT) scores and HbA1c (R 2 = 0.68); between CDT scores (R 2 = 0.51) and overall MMSE scores (R 2 = 0.43) on one hand, and DM duration in years, on the other hand; also between CDT scores and BMI (R 2 = 0.59). There was no significant association between fasting serum glucose (FSG), total serum cholesterol, LDL cholesterol or triglycerides levels and cognitive function scores (p > 0.05). The close detailed monitoring of the cognitive function and a rigorous metabolic control are important, especially in the very early stages of DM. Addressing factors such as weight control in older diabetic patients could contribute to better cognitive outcomes. |
| Databáze: | OpenAIRE |
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