Ameliorative influence ofUrtica dioicaL against cisplatin-induced toxicity in mice bearing Ehrlich ascites carcinoma
| Autor: | Ismail Koyuncu, Davut Musa, Yasin Tuluce, Halil Ozkol |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Health
Toxicology and Mutagenesis Biology Pharmacology Kidney Toxicology Blood Urea Nitrogen Ehrlich ascites carcinoma Nephrotoxicity Lipid peroxidation Mice chemistry.chemical_compound Lactate dehydrogenase Animals Carcinoma Ehrlich Tumor Urtica dioica Blood urea nitrogen Analysis of Variance Mice Inbred BALB C Chemical Health and Safety Dose-Response Relationship Drug Plant Extracts Methanol Public Health Environmental and Occupational Health Kidney metabolism General Medicine Enzymes Liver chemistry Immunology Toxicity Cisplatin |
| Zdroj: | Drug and Chemical Toxicology. 35:251-257 |
| ISSN: | 1525-6014 0148-0545 |
| DOI: | 10.3109/01480545.2011.598531 |
| Popis: | Cisplatin (CP) is a widely used cytotoxic agent against cancer, and high doses of CP have been known to cause nephrotoxicity and hepatotoxicity. Some reports claim that antioxidants can reduce CP-induced toxicity. This study investigated the hepatoprotective, nephroprotective, and antioxidant activity of Urtica dioica L methanolic extract (UDME) against CP toxicity in Erhlich ascites tumor (EAT)-bearing mice. Levels of serum hepatic enzymes, renal function markers, and oxidant/antioxidant parameters of liver tissue were measured. Mice were inoculated with EAT on day 0 and treated with nothing else for 24 hours. After a single dose of CP administration on day 1, the extract was given at the doses of 50, 100, 200, and 400 mg/kg body weight daily during 6 days. Almost all doses of UDME performed a significant (P 0.05) preventive role against CP toxicity by decreasing aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, blood urea nitrogen, creatinine, lipid peroxidation, protein oxidation levels, and myeloperoxidase activity, as well as increasing reduced glutathione content, superoxide dismutase, catalase, glutathione S-transferase, and glutathione peroxidase activities. This suggests that UDME has a protective capacity and antioxidant activity against CP toxicity in EAT-bearing mice, probably by promoting antioxidative defense systems. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|