Synthesis and biological evaluation of heteroanalogues of kotalanol and de-O-sulfonated kotalanol
| Autor: | Sankar Mohan, David R. Rose, Douglas A. Kuntz, B Mario Pinto, Kumarasamy Jayakanthan, Ravindranath Nasi |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Maltase-glucoamylase
Salacia reticulata Glycoside Hydrolase Inhibitors biology Chemistry Stereochemistry Sulfates Organic Chemistry Monosaccharides biology.organism_classification Biochemistry Intestines Structure-Activity Relationship Structure–activity relationship Organic chemistry Humans Physical and Theoretical Chemistry Enzyme Inhibitors Sulfonic Acids Biological evaluation |
| Zdroj: | Organic letters. 12(5) |
| ISSN: | 1523-7052 |
| Popis: | The synthesis of nitrogen and selenium analogues of kotalanol and de-O-sulfonated kotalanol, naturally occurring sulfonium-ion glucosidase inhibitors isolated from Salacia reticulata, and their evaluation as glucosidase inhibitors against the N-terminal catalytic domain of human maltase glucoamylase (ntMGAM) are described. |
| Databáze: | OpenAIRE |
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