No Consistent Evidence of Decreased Exposure to Varicella-Zoster Virus Among Older Adults in Countries with Universal Varicella Vaccination
| Autor: | Rafael Harpaz, Brigitte Cheuvart, Stéphane Carryn, Robbert van der Most, Giacomo Casabona, Alemnew F Dagnew, Michael Povey |
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| Rok vydání: | 2021 |
| Předmět: |
Herpesvirus 3
Human Varicella vaccine boosting viruses varicella vaccine herpes zoster medicine.disease_cause Placebo Virus Chickenpox Vaccine Major Articles and Brief Reports Immunity medicine Humans Immunology and Allergy Vaccines integumentary system biology business.industry Incidence (epidemiology) Varicella zoster virus virus diseases biochemical phenomena metabolism and nutrition eye diseases Editor's Choice AcademicSubjects/MED00290 Infectious Diseases exposure Immunology Humoral immunity biology.protein Antibody business |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Background Universal varicella vaccination might reduce opportunities for varicella-zoster virus (VZV) exposure and protective immunological boosting, thus increasing herpes zoster incidence in latently infected adults. We assessed humoral and cell-mediated immunity (CMI), as markers of VZV exposure, in adults aged ≥50 years. Methods We repurposed data from placebo recipients in a large multinational clinical trial (ZOE-50). Countries were clustered based on their varicella vaccination program characteristics, as having high, moderate, or low VZV circulation. Anti-VZV antibody geometric mean concentrations, median frequencies of VZV-specific CD4 T cells, and percentages of individuals with increases in VZV-specific CD4 T-cell frequencies were compared across countries and clusters. Sensitivity analyses using a variable number of time points and different thresholds were performed for CMI data. Results VZV-specific humoral immunity from 17 countries (12 high, 2 moderate, 3 low circulation) varied significantly between countries (P By repurposing humoral and cell-mediated immunogenicity data from a large multinational trial enrolling adults aged ≥50 years, we found no consistent evidence of differences in varicella-zoster virus exposure between countries with widely circulating varicella versus countries with universal vaccination. |
| Databáze: | OpenAIRE |
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