The sweet taste of true synergy: positive allosteric modulation of the human sweet taste receptor
| Autor: | Guy Servant, Catherine Tachdjian, Xiaodong Li, Donald S. Karanewsky |
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| Rok vydání: | 2011 |
| Předmět: |
Taste
Allosteric regulation Carbohydrates Toxicology Receptors G-Protein-Coupled Allosteric Regulation Humans Healthy weight Food science Sugar Receptor Pharmacology High-fructose corn syrup business.industry Chemistry digestive oral and skin physiology food and beverages Taste Perception Sweet taste Sweetness Taste Buds Biotechnology Sweetening Agents business Energy Intake Allosteric Site |
| Zdroj: | Trends in pharmacological sciences. 32(11) |
| ISSN: | 1873-3735 |
| Popis: | A diet low in carbohydrates helps to reduce the amount of ingested calories and to maintain a healthy weight. With this in mind, food and beverage companies have reformulated a large number of their products, replacing sugar or high fructose corn syrup with several different types of zero-calorie sweeteners to decrease or even totally eliminate their caloric content. A challenge remains, however, with the level of acceptance of some of these products in the market-place. Many consumers believe that zero-calorie sweeteners simply do not taste like sugar. A recent breakthrough reveals that positive allosteric modulators of the human sweet taste receptor, small molecules that enhance the receptor activity and sweetness perception, could be more effective than other reported taste enhancers at reducing calories in consumer products without compromising on the true taste of sugar. A unique mechanism of action at the receptor level could explain the robust synergy achieved with these new modulators. |
| Databáze: | OpenAIRE |
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