Human pharmacokinetic study of tutin in honey; a plant-derived neurotoxin
| Autor: | Barry A. Fields, Utz Mueller, Andrew Bartholomaeus, John Reeve |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Adolescent Nausea Neurotoxins Food Contamination Pharmacology Toxicology Young Adult chemistry.chemical_compound Pharmacokinetics Humans Picrotoxin Medicine Neurotoxin Coriaria arborea Dose-Response Relationship Drug biology business.industry Honey General Medicine Middle Aged Tutin biology.organism_classification Healthy Volunteers Pharmacokinetic analysis chemistry Toxicity Linear Models Vomiting medicine.symptom business Sesquiterpenes Food Science |
| Zdroj: | Food and Chemical Toxicology. 72:234-241 |
| ISSN: | 0278-6915 |
| Popis: | Over the last 150 years a number of people in New Zealand have been incapacitated, hospitalised, or died from eating honey contaminated with tutin, a plant-derived neurotoxin. A feature of the most recent poisoning incident in 2008 was the large variability in the onset time of clinical signs and symptoms of toxicity (0.5-17 h). To investigate the basis of this variability a pharmacokinetic study was undertaken in which 6 healthy males received a single oral dose of tutin-containing honey giving a tutin dose of 1.8 μg/kg body weight. The serum concentration-time curve for all volunteers exhibited two discrete peaks with the second and higher level occurring at approximately 15 h post-dose. Two subjects reported mild, transient headache at a time post-dose corresponding to maximum tutin concentrations. There were no other signs or symptoms typical of tutin intoxication such as nausea, vomiting, dizziness or seizures. Pharmacokinetic analysis using a two-site absorption model resulted in a good fit to the observed concentration data. A novel analytical method subsequently revealed the presence of glycoside conjugates of tutin in addition to unconjugated tutin in honey. These pharmacokinetic data will be important to better define a safe maximum tutin concentration in honey. |
| Databáze: | OpenAIRE |
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