Clinical and genetic changes in a case of a Cushing's carcinoma
| Autor: | N. Buckley, Richard N. Clayton, Christopher W. Perrett, M. D. Boggild, John C. Broome, E. J. Bicknell, A. S. Bates |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adenoma
Adult Male medicine.medical_specialty Pathology Heterozygote Endocrinology Diabetes and Metabolism Chromosomes Human Pair 22 Molecular Sequence Data Biology Polymerase Chain Reaction Metastasis Loss of heterozygosity Endocrinology Internal medicine Carcinoma medicine Humans Pituitary Neoplasms Cushing Syndrome DNA Primers Autosome Epithelioma Base Sequence Chromosomes Human Pair 10 Chromosomes Human Pair 11 Heterozygote advantage medicine.disease Immunohistochemistry Chromosomes Human Pair 1 Chromosomes Human Pair 3 Tumor Suppressor Protein p53 Immunostaining Gene Deletion |
| Zdroj: | Clinical endocrinology. 42(6) |
| ISSN: | 0300-0664 |
| Popis: | A 30-year-old presented in 1984 with a clinically nonfunctional tumour which subsequently developed into a metastatic corticotrophinoma from which he died despite surgery in 1984, 1986 and 1991 and external radiotherapy in 1986. Molecular genetic analysis of tumour and metastatic tissue revealed loss of heterozygosity at loci on the autosomes 1p, 3p, 10q26, 11q13 and 22q12. Tissue taken at surgery in 1986 also revealed positive cytoplasmic immunostaining for p53 protein. No such staining was evident in tissue taken at first surgery in 1984. Further analysis of invasive pituitary adenomas may reveal loci associated with such behaviour, enabling better prediction of subsequent clinical outcome than is possible using standard histological techniques, and delivery of early, aggressive treatment to those tumours which show molecular markers associated with a poor prognosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text