Injury to the blood-testis barrier after low-dose-rate chronic radiation exposure in mice
| Autor: | C. G. Lee, W. S. Cho, Min Young Lee, S. D. Kim, K. Yang, In Sik Shin, K. Heo, Ji-In Kim, Y. Son, M. J. Bae |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pathology medicine.medical_specialty Male mice Radiation Dosage Male infertility Ionizing radiation Andrology Mice Testis Animals Medicine Radiology Nuclear Medicine and imaging Low dose rate Radiation Injuries Blood-Testis Barrier Infertility Male Blood–testis barrier Mice Inbred BALB C Radiation Radiological and Ultrasound Technology biology business.industry Chronic radiation syndrome Public Health Environmental and Occupational Health Dose-Response Relationship Radiation General Medicine Radiation Exposure medicine.disease Radiation Injuries Experimental Male fertility biology.protein Antibody business |
| Zdroj: | Radiation Protection Dosimetry. 167:316-320 |
| ISSN: | 1742-3406 0144-8420 |
| DOI: | 10.1093/rpd/ncv270 |
| Popis: | Exposure to ionising radiation induces male infertility, accompanied by increasing permeability of the blood-testis barrier. However, the effect on male fertility by low-dose-rate chronic radiation has not been investigated. In this study, the effects of low-dose-rate chronic radiation on male mice were investigated by measuring the levels of tight-junction-associated proteins (ZO-1 and occludin-1), Niemann-Pick disease type 2 protein (NPC-2) and antisperm antibody (AsAb) in serum. BALB/c mice were exposed to low-dose-rate radiation (3.49 mGy h(-1)) for total exposures of 0.02 (6 h), 0.17 (2 d) and 1.7 Gy (21 d). Based on histological examination, the diameter and epithelial depth of seminiferous tubules were significantly decreased in 1.7-Gy-irradiated mice. Compared with those of the non-irradiated group, 1.7-Gy-irradiated mice showed significantly decreased ZO-1, occludin-1 and NPC-2 protein levels, accompanied with increased serum AsAb levels. These results suggest potential blood-testis barrier injury and immune infertility in male mice exposed to low-dose-rate chronic radiation. |
| Databáze: | OpenAIRE |
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