The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients
| Autor: | Canovi, S., Besutti, G., Bonelli, E., Iotti, V., Ottone, M., Albertazzi, L., Zerbini, A., Pattacini, P., Giorgi Rossi, P., Colla, R., Fasano, T., Costantini, M., Grilli, R., Marino, M., Formoso, G., Formisano, D., Rossi, P. G., Bedeschi, E., Perilli, C., La Rosa, E., Bisaccia, E., Venturi, I., Vicentini, M., Campari, C., Gioia, F., Broccoli, S., Spaggiari, L., Mancuso, P., Nitrosi, A., Foracchia, M., Massari, M., Ferrari, A. M., Pinotti, M., Facciolongo, N., Lattuada, I., Trabucco, L., De Pietri, S., Danelli, G. F., Bellesia, E., Corradini, M., Magnani, E., Pilia, A., Polese, A., Incerti, S. S., Zaldini, P., Orsola, B., Revelli, M., Salvarani, C., Pinto, C., Venturelli, F. |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Clinical laboratory Cross-sectional study Computed tomography COVID-19 Severity of Illness Index Gastroenterology Procalcitonin lcsh:Infectious and parasitic diseases 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Severity of illness medicine Humans lcsh:RC109-216 Lymphocyte Count 030212 general & internal medicine Lung Retrospective Studies Oxygen saturation (medicine) Creatinine business.industry Retrospective cohort study Middle Aged Prognosis Oxygen C-Reactive Protein Cross-Sectional Studies Infectious Diseases medicine.anatomical_structure Italy chemistry Cohort Female Tomography X-Ray Computed business Research Article |
| Zdroj: | BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-9 (2021) BMC Infectious Diseases |
| ISSN: | 1471-2334 |
| Popis: | Background Laboratory data and computed tomography (CT) have been used during the COVID-19 pandemic, mainly to determine patient prognosis and guide clinical management. The aim of this study was to evaluate the association between CT findings and laboratory data in a cohort of COVID-19 patients. Methods This was an observational cross-sectional study including consecutive patients presenting to the Reggio Emilia (Italy) province emergency rooms for suspected COVID-19 for one month during the outbreak peak, who underwent chest CT scan and laboratory testing at presentation and resulted positive for SARS-CoV-2. Results Included were 866 patients. Total leukocytes, neutrophils, C-reactive protein (CRP), creatinine, AST, ALT and LDH increase with worsening parenchymal involvement; an increase in platelets was appreciable with the highest burden of lung involvement. A decrease in lymphocyte counts paralleled worsening parenchymal extension, along with reduced arterial oxygen partial pressure and saturation. After correcting for parenchymal extension, ground-glass opacities were associated with reduced platelets and increased procalcitonin, consolidation with increased CRP and reduced oxygen saturation. Conclusions Pulmonary lesions induced by SARS-CoV-2 infection were associated with raised inflammatory response, impaired gas exchange and end-organ damage. These data suggest that lung lesions probably exert a central role in COVID-19 pathogenesis and clinical presentation. |
| Databáze: | OpenAIRE |
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