Enhanced Synaptic Integration of Adult-Born Neurons in the Olfactory Bulb of Lactating Mothers
Autor: | Eitan Schechtman, Maya Groysman, Hagit Kopel, Adi Mizrahi |
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Rok vydání: | 2012 |
Předmět: |
Male
medicine.medical_specialty Dendritic spine Offspring Dendritic Spines Genetic Vectors Green Fluorescent Proteins Synaptophysin Biology Statistics Nonparametric Cellular mechanism Mice 03 medical and health sciences 0302 clinical medicine Pregnancy Transduction Genetic Internal medicine Neural Pathways medicine Animals Lactation Stem Cell Niche 030304 developmental biology Neurons Analysis of Variance Mice Inbred BALB C 0303 health sciences Microscopy Confocal Neuronal Plasticity Synaptic integration General Neuroscience Articles Anatomy Olfactory Bulb Olfactory bulb Brain region Endocrinology Animals Newborn Gene Expression Regulation Neuronal circuits Synapses Female 030217 neurology & neurosurgery |
Zdroj: | Journal of Neuroscience |
ISSN: | 1529-2401 0270-6474 |
Popis: | One of the most dramatic events during the life of adult mammals is the transition into motherhood. This transition is accompanied by specific maternal behaviors, displayed by the mother, that ensure the survival and the well-being of her offspring. The execution of these behaviors is most likely accompanied by plastic changes in specific neuronal circuits, but these are still poorly defined. In this work, we studied the mammalian olfactory bulb (OB), which has been shown to be an essential brain region for maternal behaviors in mice. In the OB, we focused on adult-born neurons, which are continuously incorporated into the circuit during adulthood, thus providing a potential substrate for heightened plasticity after parturition. We analyzed the dynamics and morphological characteristics of adult-born granule cells (abGCs), innervating the OB of primiparous lactating mothers, shortly after parturition as well as in naive females.In vivotime-lapse imaging of abGCs revealed that dendritic spines were significantly more stable in lactating mothers compared with naive virgins. In contrast, spine stability of resident GCs remained unchanged after parturition. In addition, while spine size distribution of abGCs was approximately similar between mothers and naive virgins, the spine density of abGCs was lower in lactating mothers and the density of their presynaptic components was higher. These structural features are indicative of enhanced integration of adult-born neurons into the bulbar circuitry of lactating mothers. This enhanced integration may serve as a cellular mechanism, supporting changes in olfactory coding of new mothers during their first days following parturition. |
Databáze: | OpenAIRE |
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