Dietary supplementation with conjugated linoleic acid plus n-3 polyunsaturated fatty acid increases food intake and brown adipose tissue in rats

Autor: D. Vernon Rayner, Shabina Bashir, Sharon E. Mitchell, Alan A. Sneddon, Lynda Williams, Amanda C. Morris, K. W. Wahle, Jung-Heun Ha
Rok vydání: 2009
Předmět:
Blood Glucose
Male
medicine.medical_specialty
Conjugated linoleic acid
Linoleic acid
media_common.quotation_subject
Adipose Tissue
White
brain
Adipose tissue
Muscle Proteins
lcsh:TX341-641
White adipose tissue
Weight Gain
n-3 long chain polyunsaturated fatty acid
Article
conjugated linoleic acid
chemistry.chemical_compound
Eating
Random Allocation
Adipose Tissue
Brown
white adipose tissue
Internal medicine
Brown adipose tissue
Fatty Acids
Omega-3
medicine
Animals
Linoleic Acids
Conjugated
hypothalamus
media_common
chemistry.chemical_classification
Nutrition and Dietetics
Triglyceride
Appetite
brown adipose tissue
Animal Feed
Lipids
Rats
medicine.anatomical_structure
Endocrinology
chemistry
Gene Expression Regulation
Dietary Supplements
lcsh:Nutrition. Foods and food supply
Food Science
Polyunsaturated fatty acid
Zdroj: Nutrients
Nutrients; Volume 1; Issue 2; Pages: 178-196
Nutrients, Vol 1, Iss 2, Pp 178-196 (2009)
ISSN: 2072-6643
Popis: The effect of supplementation with 1% conjugated linoleic acid and 1% n-3 long chain polyunsaturated fatty acids (CLA/n-3) was assessed in rats. Food intake increased with no difference in body weights. White adipose tissue weights were reduced whereas brown adipose tissue and uncoupling protein-1 expression were increased. Plasma adiponectin, triglyceride and cholesterol levels were reduced while leptin, ghrelin and liver weight and lipid content were unchanged. Hypothalamic gene expression measurements revealed increased expression of orexigenic and decreased expression of anorexigenic signals. Thus, CLA/n-3 increases food intake without affecting body weight potentially through increasing BAT size and up-regulating UCP-1 in rats.
Databáze: OpenAIRE
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