Postfolate spina bifida lesion level change
| Autor: | Timothy J. Flood, Jennifer Andrews, Sruti Bandlamuri, Dianna Contreras, Maureen K. Galindo, Sydney A. Rice, Carin Eldridge |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine congenital hereditary and neonatal diseases and abnormalities Embryology Pediatrics medicine.medical_specialty Health Toxicology and Mutagenesis 030105 genetics & heredity Toxicology Lesion Young Adult 03 medical and health sciences Folic Acid 0302 clinical medicine Neurologic function 030225 pediatrics medicine Humans Spinal Dysraphism business.industry Spina bifida Medical record Significant difference medicine.disease Hydrocephalus Sample size determination Food Fortified Pediatrics Perinatology and Child Health Hispanic ethnicity Female medicine.symptom business Developmental Biology |
| Zdroj: | Birth Defects Research. 110:949-955 |
| ISSN: | 2472-1727 |
| DOI: | 10.1002/bdr2.1221 |
| Popis: | BACKGROUND Spina bifida accounts for a large proportion of birth defects in the United States. Studies have evaluated the decrease in prevalence at birth after folate fortification of food grains, but little is known about neurologic functional changes related to fortification. This study assesses the functional level of lesions in the prefortification and postfortification eras. METHODS Data were collected through retrospective review of medical records from a regional multispecialty clinic in Arizona. This study included individuals born between 1981-1995 (prefortification) and 1999-2013 (postfortification). Patients were included if they had a primary diagnosis of spina bifida with or without hydrocephalus. RESULTS There was a significant difference in functional lesion level with an 85% reduction in thoracic level lesions in the postfortification era (p |
| Databáze: | OpenAIRE |
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