Cortisol response to stress in schizophrenia: associations with oxytocin, social support and social functioning
| Autor: | Cumhur Tas, Elliot C. Brown, Gökçer Eskikurt, Sezen Irmak, Orkun Aydın, Aysen Esen-Danaci, Martin Brüne |
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| Přispěvatelé: | İstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Eskikurt, Gokcer, Department of Psychology, Uskudar University, Istanbul, Turkey, Research Department of Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, Department of Psychiatry, LWL University Hospital, Ruhr-University Bochum, Germany, Mathison Centre for Mental Health Research and Education / Hotchkiss Brain Institute, University of Calgary, Alberta, Canada, Department of Physiology, Faculty of Medicine, Istinye University, Istanbul, Turkey, Department of Biochemistry, Celal Bayar University Hospital Manisa, Turkey, Department of Psychiatry, Celal Bayar University Hospital Manisa, Turkey |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male endocrine system Hydrocortisone Population Oxytocin Stress Cortisol Young Adult 03 medical and health sciences Social support 0302 clinical medicine Humans Medicine Young adult Social Behavior education Biological Psychiatry Social Functioning education.field_of_study business.industry Stressor Social Support Middle Aged medicine.disease 030227 psychiatry Psychiatry and Mental health Schizophrenia Female Schizophrenic Psychology business Stress Psychological 030217 neurology & neurosurgery Glucocorticoid hormones hormone substitutes and hormone antagonists medicine.drug Clinical psychology |
| ISSN: | 0004-5497 |
| Popis: | Previous studies reported attenuated cortisol reactivity as one explanation for poor social functioning in schizophrenia. Recent research has demonstrated that both glucocorticoid and oxytocin systems are central to stress regulation. Here, we studied the associations between basal oxytocin, stress-induced cortisol levels, and social functioning and social support in schizophrenia. A mock job interview was used as an ecologically-valid social stressor in 32 schizophrenia patients. Blood samples were taken before and after stress induction to assess basal oxytocin and cortisol levels. In addition social functioning and social support scales were collected. Patients were divided into cortisol responders and non-responders according to percentage change following stress induction. Our findings revealed a possible subgroup of patients who did not exhibit attenuated cortisol responses. Importantly, cortisol responders had generally better social functioning, but perceived social support was not different between groups. There was also no evidence of a relationship between cortisol and oxytocin. This study highlights the heterogeneity of cortisol responses to stress in a schizophrenia population, and the importance of the relationship between social functioning and cortisol reactivity. These findings could be relevant when considering therapeutic interventions that manipulate endocrinology in order to improve real-world functioning. Ruhr University Research School - TUBITAK (The Scientific and Technological Research Council of Turkey) foreign researcher fellowship Ruhr University Research School funded the costs for the biochemical kits. Dr Brown was funded by a TUBITAK (The Scientific and Technological Research Council of Turkey) foreign researcher fellowship for the partial duration of this study. There are no conflicts of interest. WOS:000454972600148 29960725 Q2 |
| Databáze: | OpenAIRE |
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