Genes, Ageing and Longevity in Humans: Problems, Advantages and Perspectives

Autor: Laura Celani, Stefano Salvioli, Miriam Capri, Francesca Marchegiani, G. De Benedictis, Calogero Caruso, Aurelia Santoro, Michele Mishto, Claudio Franceschi, Maurizio Cardelli, Giuseppe Paolisso, Efstathios S. Gonos, Fabiola Olivieri, Elena Bellavista, Elisa Cevenini, Laura Invidia, Daniela Monti, Federica Sevini, Francesco Lescai, Silvana Valensin
Přispěvatelé: Salvioli S., Olivieri F., Marchegiani F., Cardelli M., Santoro A., Bellavista E., Mishto M., Invidia L., Capri M., Valensin S., Sevini F., Lescai F., Gonos E., Caruso C., Paolisso G., De Benedictis G., Monti D., Franceschi C., SALVIOLI S, OLIVIERI F, MARCHEGIANI F, CARDELLI M, SANTORO A, BELLAVISTA E, MISHTO M, INVIDIA L, CAPRI M, VALENSIN S, SEVINI F, CEVENINI E, CELANI L, LESCAI F, GONOS E, CARUSO C, PAOLISSO G, DE BENEDICTIS G, MONTI D, FRANCESCHI C, Salvioli, S, Olivieri, F, Marchegiani, F, Cardelli, M, Santoro, A, Bellavista, E, Mishto, M, Invidia, L, Capri, M, Valensin, S, Sevini, F, Cevenini, E, Celani, L, Lescai, F, Gonos, E, Caruso, C, Paolisso, Giuseppe, DE BENEDICTIS, G, Monti, D, Franceschi, C.
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Mitochondrial DNA
Aging
Proteasome Endopeptidase Complex
Nuclear gene
Apolipoproteins
genetics

Insulin-Like Growth Factor I
genetics

media_common.quotation_subject
Apolipoprotein E4
Longevity
Biology
Genetic polymorphisms
ageing
longevity
centenarians
association studies
mitochondrial DNA

Biochemistry
DNA
Mitochondrial

Inflammation
genetics

Apolipoprotein E4
genetics

Cytokines
genetics

Animals
Humans
Allele
Insulin-Like Growth Factor I
Longevity
genetics

Gene
media_common
Genetic association
Genetics
Aged
80 and over

Inflammation
Polymorphism
Genetic

Aryldialkylphosphatase
Superoxide Dismutase
Superoxide Dismutase
genetics

General Medicine
Clusterin
genetics

Poly(ADP-ribose) Polymerases
genetics

Aging
genetics

Apolipoproteins
Clusterin
Tumor Suppressor Protein p53
genetics

Genes
Evolutionary biology
Trait
Cytokines
Gene pool
Poly(ADP-ribose) Polymerases
Tumor Suppressor Protein p53
Aryldialkylphosphatase
genetics

DNA
Mitochondrial
genetics

Proteasome Endopeptidase Complex
physiology
Zdroj: Salvioli, S, Olivieri, F, Marchegiani, F, Cardelli, M, Santoro, A, Bellavista, E, Mishto, M, Invidia, L, Capri, M, Valensin, S, Sevini, F, Cevenini, E, Celani, L, Lescai, F, Gonos, E, Caruso, C, Paolisso, G, Benedictis, G D, Monti, D & Franceschi, C 2006, ' Genes, ageing and longevity in humans: problems, advantages and perspectives. ', Free Radical Research, bind 40, nr. 12, s. 1303-1323 . https://doi.org/10.1080/10715760600917136
DOI: 10.1080/10715760600917136
Popis: Many epidemiological data indicate the presence of a strong familial component of longevity that is largely determined by genetics, and a number of possible associations between longevity and allelic variants of genes have been described. A breakthrough strategy to get insight into the genetics of longevity is the study of centenarians, the best example of successful ageing. We review the main results regarding nuclear genes as well as the mitochondrial genome, focusing on the investigations performed on Italian centenarians, compared to those from other countries. These studies produced interesting results on many putative "longevity genes". Nevertheless, many discrepancies are reported, likely due to the population-specific interactions between gene pools and environment. New approaches, including large-scale studies using high-throughput techniques, are urgently needed to overcome the limits of traditional association studies performed on a limited number of polymorphisms in order to make substantial progress to disentangle the genetics of a trait as complex as human longevity.
Databáze: OpenAIRE