Genes, Ageing and Longevity in Humans: Problems, Advantages and Perspectives
Autor: | Laura Celani, Stefano Salvioli, Miriam Capri, Francesca Marchegiani, G. De Benedictis, Calogero Caruso, Aurelia Santoro, Michele Mishto, Claudio Franceschi, Maurizio Cardelli, Giuseppe Paolisso, Efstathios S. Gonos, Fabiola Olivieri, Elena Bellavista, Elisa Cevenini, Laura Invidia, Daniela Monti, Federica Sevini, Francesco Lescai, Silvana Valensin |
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Přispěvatelé: | Salvioli S., Olivieri F., Marchegiani F., Cardelli M., Santoro A., Bellavista E., Mishto M., Invidia L., Capri M., Valensin S., Sevini F., Lescai F., Gonos E., Caruso C., Paolisso G., De Benedictis G., Monti D., Franceschi C., SALVIOLI S, OLIVIERI F, MARCHEGIANI F, CARDELLI M, SANTORO A, BELLAVISTA E, MISHTO M, INVIDIA L, CAPRI M, VALENSIN S, SEVINI F, CEVENINI E, CELANI L, LESCAI F, GONOS E, CARUSO C, PAOLISSO G, DE BENEDICTIS G, MONTI D, FRANCESCHI C, Salvioli, S, Olivieri, F, Marchegiani, F, Cardelli, M, Santoro, A, Bellavista, E, Mishto, M, Invidia, L, Capri, M, Valensin, S, Sevini, F, Cevenini, E, Celani, L, Lescai, F, Gonos, E, Caruso, C, Paolisso, Giuseppe, DE BENEDICTIS, G, Monti, D, Franceschi, C. |
Jazyk: | angličtina |
Rok vydání: | 2006 |
Předmět: |
Mitochondrial DNA
Aging Proteasome Endopeptidase Complex Nuclear gene Apolipoproteins genetics Insulin-Like Growth Factor I genetics media_common.quotation_subject Apolipoprotein E4 Longevity Biology Genetic polymorphisms ageing longevity centenarians association studies mitochondrial DNA Biochemistry DNA Mitochondrial Inflammation genetics Apolipoprotein E4 genetics Cytokines genetics Animals Humans Allele Insulin-Like Growth Factor I Longevity genetics Gene media_common Genetic association Genetics Aged 80 and over Inflammation Polymorphism Genetic Aryldialkylphosphatase Superoxide Dismutase Superoxide Dismutase genetics General Medicine Clusterin genetics Poly(ADP-ribose) Polymerases genetics Aging genetics Apolipoproteins Clusterin Tumor Suppressor Protein p53 genetics Genes Evolutionary biology Trait Cytokines Gene pool Poly(ADP-ribose) Polymerases Tumor Suppressor Protein p53 Aryldialkylphosphatase genetics DNA Mitochondrial genetics Proteasome Endopeptidase Complex physiology |
Zdroj: | Salvioli, S, Olivieri, F, Marchegiani, F, Cardelli, M, Santoro, A, Bellavista, E, Mishto, M, Invidia, L, Capri, M, Valensin, S, Sevini, F, Cevenini, E, Celani, L, Lescai, F, Gonos, E, Caruso, C, Paolisso, G, Benedictis, G D, Monti, D & Franceschi, C 2006, ' Genes, ageing and longevity in humans: problems, advantages and perspectives. ', Free Radical Research, bind 40, nr. 12, s. 1303-1323 . https://doi.org/10.1080/10715760600917136 |
DOI: | 10.1080/10715760600917136 |
Popis: | Many epidemiological data indicate the presence of a strong familial component of longevity that is largely determined by genetics, and a number of possible associations between longevity and allelic variants of genes have been described. A breakthrough strategy to get insight into the genetics of longevity is the study of centenarians, the best example of successful ageing. We review the main results regarding nuclear genes as well as the mitochondrial genome, focusing on the investigations performed on Italian centenarians, compared to those from other countries. These studies produced interesting results on many putative "longevity genes". Nevertheless, many discrepancies are reported, likely due to the population-specific interactions between gene pools and environment. New approaches, including large-scale studies using high-throughput techniques, are urgently needed to overcome the limits of traditional association studies performed on a limited number of polymorphisms in order to make substantial progress to disentangle the genetics of a trait as complex as human longevity. |
Databáze: | OpenAIRE |
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