An exploratory analysis of the competing effects of alcohol use and advanced hepatic fibrosis on serum HDL
| Autor: | Augustin G. L. Vannier, Amanda PeBenito, Raymond T. Chung, Esperance A. Schaefer, Jay Luther, Vladislav G Fomin, Russell P. Goodman |
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| Rok vydání: | 2021 |
| Předmět: |
Liver Cirrhosis
medicine.medical_specialty Alcohol Drinking Alcohol Negative association Gastroenterology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Liver disease chemistry.chemical_compound 0302 clinical medicine Non-alcoholic Fatty Liver Disease Internal medicine Humans Medicine In patient 030212 general & internal medicine Hematology business.industry General Medicine Exploratory analysis medicine.disease Cross-Sectional Studies chemistry Baseline characteristics 030211 gastroenterology & hepatology business Hepatic fibrosis |
| Zdroj: | Clinical and Experimental Medicine. 22:103-110 |
| ISSN: | 1591-9528 1591-8890 |
| Popis: | While alcohol use has been shown to increase serum HDL, advanced liver disease associates with decreased serum HDL. The combined influence of alcohol consumption and liver fibrosis is poorly defined. In this study, we sought to investigate the competing effects of alcohol use and hepatic fibrosis on serum HDL and to determine if the presence of advanced hepatic fibrosis ablates the reported effect of alcohol consumption on serum HDL. We performed a cross-sectional, exploratory analysis examining the interaction between alcohol use and advanced hepatic fibrosis on serum HDL levels in 10,528 patients from the Partners Biobank. Hepatic fibrosis was assessed using the FIB-4 index. We excluded patients with baseline characteristics that affect serum HDL, independent of alcohol use or the presence or advanced hepatic fibrosis. We observed an incremental correlation between increasing HDL levels and amount of alcohol consumed (P Pvalue: 0.0001). Finally, when comparing subjects with advanced hepatic fibrosis who do not use alcohol to those who do, we observed that alcohol use is associated with increased HDL levels (54.58 mg/dL vs 67.26 mg/dL,p = 0.0009). This HDL-elevating effect of alcohol was more pronounced than that seen in patients without evidence of advanced hepatic fibrosis (60.88 mg/dL vs 67.93 mg/dL,p |
| Databáze: | OpenAIRE |
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