Immunobiological specificity of antibodies against glutamate and gamma-aminobutyric acid
| Autor: | L. A. Vetrile, V. A. Evseev, L. V. Kuznetsova, N. A. Trekova, N. Yu. Klishina, M. N. Karpova |
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| Rok vydání: | 2008 |
| Předmět: |
Male
biology Kindling Chemistry Glutamate decarboxylase Glutamate receptor Autoantibody Glutamic Acid Enzyme-Linked Immunosorbent Assay General Medicine Pharmacology Aminobutyric acid General Biochemistry Genetics and Molecular Biology Antibodies Mice Inbred C57BL Mice nervous system Antibody Specificity biology.protein Immunohistochemistry Animals Antibody gamma-Aminobutyric Acid |
| Zdroj: | Bulletin of experimental biology and medicine. 143(5) |
| ISSN: | 0007-4888 |
| Popis: | Experiments on C57Bl/6 mice showed that chronic epileptization of the brain (pharmacological pentylenetetrazole kindling) is accompanied by induction of autoantibodies against glutamate and GABA. Immunohistochemical similarity of antibodies against glutamate and GABA was demonstrated. Study on the model of pentylenetetrazole-induced acute generalized epileptiform activity showed high immunobiological specificity of intraperitoneally injected antibodies against GABA and glutamate: antiepileptic effect of antiglutamate antibodies and proepileptic effect of antibodies against GABA. |
| Databáze: | OpenAIRE |
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