Post-challenge glucose predicts coronary atherosclerotic progression in non-diabetic, post-menopausal women
| Autor: | David M. Herrington, P. B. Mellen, Vera Bittner |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Endocrinology Diabetes and Metabolism Coronary Angiography Impaired glucose tolerance Cohort Studies Endocrinology Predictive Value of Tests Diabetes mellitus Internal medicine Internal Medicine medicine Humans Coronary atherosclerosis Aged Vascular disease business.industry Glucose Tolerance Test medicine.disease Atherosclerosis Obesity Postmenopause Blood pressure Treatment Outcome Quartile Cardiology Disease Progression Female business Body mass index Biomarkers |
| Zdroj: | Diabetic medicine : a journal of the British Diabetic Association. 24(10) |
| ISSN: | 0742-3071 |
| Popis: | AIMS: We sought to determine whether fasting or post-challenge glucose were associated with progression of coronary atherosclerosis in non-diabetic women. METHODS: We performed a post-hoc analysis of 132 non-diabetic women who underwent 75-g oral glucose tolerance testing. The primary outcome of interest was progression of atherosclerosis determined by baseline and follow-up coronary angiography, a mean of 3.1 +/- 0.9 years apart. We analysed the association of change in minimal vessel diameter (DeltaMD) by quartile of fasting and post-challenge glucose using mixed models that included adjustment for age, systolic blood pressure, total : high-density lipoprotein cholesterol ratio, current smoking, lipid-lowering and anti-hypertensive medication use and other covariates. RESULTS: At baseline, participants had a mean age of 65.7 +/- 6.7 years and a mean body mass index of 27.9 +/- 8.5 kg/m(2). Although there were no significant differences in atherosclerotic progression by fasting glucose category (P for trend across quartiles = 0.99), there was a significant inverse association between post-challenge glucose and DeltaMD (in mm) (Q1 : 0.01 +/- 0.03; Q2 : 0.08 +/- 0.03; Q3 : 0.13 +/- 0.03; Q4 : 0.11 +/- 0.03; P for trend = 0.02). CONCLUSIONS: In post-menopausal women without diabetes, post-challenge glucose predicts angiographic disease progression. These findings suggest that even modest post-challenge hyperglycaemia influences the pathogenesis of atherosclerotic progression. |
| Databáze: | OpenAIRE |
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