Lack of association between monocyte protein-1 (MCP-1) –2518 A > G chemoattractant and C–C chemokine receptor 2 (CCR2) Val64Ile polymorphisms and multiple sclerosis in a Tunisian population
| Autor: | Amani Kallel, S. Laayouni, A. Messadi, C. Bouguerra, Nasredine Gritli, R. Jemaa, Brahim Nciri, M. Yedeas, Naziha Kaabachi, J. Zaweli, Yousra Sediri, N. Fekih-Mrissa, Ridha Mrissa |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male CCR2 Chemokine Multiple Sclerosis Tunisia Adolescent Genotype Receptors CCR2 Inflammation Biology Polymorphism Single Nucleotide CCL8 Young Adult Chemokine receptor Gene Frequency Physiology (medical) Confidence Intervals Odds Ratio medicine Humans Isoleucine Child Receptor Chemokine CCL2 Multiple sclerosis Monocyte Valine General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Molecular biology medicine.anatomical_structure Neurology Immunology biology.protein Female Surgery Neurology (clinical) medicine.symptom Genome-Wide Association Study |
| Zdroj: | Journal of Clinical Neuroscience. 17:1311-1313 |
| ISSN: | 0967-5868 |
| Popis: | Chemokines and their receptors are known to mediate inflammation and tissue damage in autoimmune disorders such as multiple sclerosis (MS). Multiple sclerosis is an inflammatory disease of the central nervous system, characterized by myelin damage and neurological complications. Monocyte chemoattractant protein-1 (MCP-1) interacts with the C–C chemokine receptor 2 (CCR2) and plays a role in the migration of leukocytes into the central nervous system, thus contributing to the T cell-mediated pathogenesis of MS. Genomic DNA obtained from 58 MS patients and 72 healthy controls was tested for the MCP-1 –2518 A > G and CCR2 Val64Ile polymorphisms using polymerase chain reaction–restriction fragment length polymorphism analysis. Neither the MCP-1 –2518G (p = 0.43) nor the CCR2 64Ile (p = 0.52) variant contributed to the risk of MS in Tunisians. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect