Whole Ovary Cryopreservation and Transplantation: A Systematic Review of Challenges and Research Developments in Animal Experiments and Humans
| Autor: | Camille Hossay, Jacques Donnez, Marie-Madeleine Dolmans |
|---|---|
| Přispěvatelé: | UCL - SSS/IREC/GYNE - Pôle de Gynécologie, UCL - (SLuc) Service de gynécologie et d'andrologie |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
vascular anastomosis whole ovary Reproductive medicine lcsh:Medicine Ovary Review Bioinformatics cryopreservation Cryopreservation 03 medical and health sciences Follicle 0302 clinical medicine medicine Endocrine system Ovarian tissue cryopreservation Fertility preservation 030304 developmental biology 0303 health sciences 030219 obstetrics & reproductive medicine business.industry lcsh:R General Medicine microsurgery Transplantation medicine.anatomical_structure business |
| Zdroj: | Journal of Clinical Medicine, Vol 9, Iss 3196, p 3196 (2020) Journal of Clinical Medicine Journal of Clinical Medicine, Vol. 9, no. 10, p. 3196 [1-30] (2020) |
| ISSN: | 2077-0383 |
| Popis: | Ovarian tissue cryopreservation and transplantation is the only fertility preservation option that enables both restoration of fertility and resumption of ovarian endocrine function, avoiding the morbidity associated with premature menopause. It is also the only technique available to prepubertal patients and those whose treatment cannot be delayed for life-threatening reasons. Ovarian tissue cryopreservation can be carried out in two different ways, either as ovarian cortical fragments or as a whole organ with its vascular pedicle. Although use of cortical strips is the only procedure that has been approved by the American Society for Reproductive Medicine, it is fraught with drawbacks, the major one being serious follicle loss occurring after avascular transplantation due to prolonged warm ischemia. Whole ovary cryopreservation involves vascular transplantation, which could theoretically counteract the latter phenomenon and markedly improve follicle survival. In theory, this technique should maintain endocrine and reproductive functions much longer than grafting of ovarian cortical fragments. However, this procedure includes a number of critical steps related to (A) the level of surgical expertise required to accomplish retrieval of a whole ovary with its vascular pedicle, (B) the choice of cryopreservation technique for freezing of the intact organ, and (C) successful execution of functional vascular reanastomosis upon thawing. The aim of this systematic review is to shed light on these challenges and summarize solutions that have been proposed so far in animal experiments and humans in the field of whole ovary cryopreservation and transplantation. |
| Databáze: | OpenAIRE |
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