The influence of reticuloendothelial stimulation on the response of rats to dietary cholesterol*
| Autor: | N. R. Di Luzio, S. J. Riggi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1962 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Cholesterol Zymosan Stimulation Cell Biology Mononuclear phagocyte system QD415-436 Hyperplasia Biology medicine.disease Biochemistry chemistry.chemical_compound Endocrinology chemistry Oral administration Internal medicine Blood plasma medicine Glucan |
| Zdroj: | Journal of Lipid Research, Vol 3, Iss 3, Pp 339-343 (1962) |
| ISSN: | 0022-2275 |
| Popis: | SUMMARY The influence of zymosan, and of various chemical fractions obtained from the yeast cell wall, on lipid alterations induced by the feeding of a cholesterol-cholate diet to rats was studied. Intravenous administration of zymosan produced pronounced stimulation and hyperplasia of the reticuloendothelial system, and a reduction in hepatic and plasma accumulation of ester cholesterol. Oral administration of zymosan was ineffective. Glucan, and other fractions derived from zymosan that stimulated the reticuloendothelial system, significantly inhibited dietary-induced hepatic cholesterosis. The results are indicative of a relationship between the functional activity of the reticuloendothelial system and cholesterol metabolism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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